Loss of p53 function is invariably associated with cancer. Its role in tumor growth was
recently linked to its effects on cancer stem cells (CSCs), although the underlying molecular …

The p53 transcription factor is a master regulator of cellular responses to stress that is
commonly inactivated in diverse cancer types. Despite decades of research, the …

Abstract p53 is well known as a “guardian of the genome” for differentiated cells, in which it
induces cell cycle arrest and cell death after DNA damage and thus contributes to the …

Cancer stem cells (CSCs) modify and form their microenvironment by recruiting and
activating specific cell types such as mesenchymal stem cells (MSCs). Tumor-infiltrating …

Simple Summary Sarcomas are rare cancers of mesenchymal origin, the majority of which
are characterized by many copy number alterations, amplifications, or deletions. Because of …

Cancer stem cells (CSCs) may serve as the cellular seeds of tumor recurrence and
metastasis, and they can be generated via epithelial-mesenchymal transitions (EMTs) …

One of the theories on cancer stem cells (CSCs) states that these cells initiate most tumors
and give rise to more-or-less differentiated tumor cells. Genetic signatures of CSCs are …

Head and neck cancers are deadly diseases that are diagnosed annually in approximately
half a million individuals worldwide. Growing evidence supporting a role for cancer stem …

Genomic aberrations have been identified in many human pluripotent stem cell (hPSC)
cultures. Commonly observed duplications in portions of chromosomes 12p and 17q have …

The tumor suppressor, p53, plays a critical role in suppressing osteosarcoma. Bone marrow
stromal cells (BMSCs, also known as bone marrow-derived mesenchymal stem cells) have …