Amino acid catabolism: a pivotal regulator of innate and adaptive immunity
Enhanced amino acid catabolism is a common response to inflammation, but the
immunologic significance of altered amino acid consumption remains unclear. The finding …
immunologic significance of altered amino acid consumption remains unclear. The finding …
Amino assets: how amino acids support immunity
Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …
is well defined, but they contribute to a host of other intracellular metabolic pathways …
Control of immune response by amino acid metabolism
U Grohmann, V Bronte - Immunological reviews, 2010 - Wiley Online Library
The interaction between pathogenic microorganisms and their hosts is regulated by
reciprocal survival strategies, including competition for essential nutrients. Though …
reciprocal survival strategies, including competition for essential nutrients. Though …
Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity
Y Zheng, Y Yao, T Ge, S Ge, R Jia, X Song… - Journal of Experimental …, 2023 - Springer
Metabolic reprogramming of amino acids has been increasingly recognized to initiate and
fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of …
fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of …
Carbohydrate and amino acid metabolism as hallmarks for innate immune cell activation and function
Immune activation is now understood to be fundamentally linked to intrinsic and/or extrinsic
metabolic processes which are essential for immune cells to survive, proliferate, and perform …
metabolic processes which are essential for immune cells to survive, proliferate, and perform …
Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
L Yang, Z Chu, M Liu, Q Zou, J Li, Q Liu… - Journal of hematology & …, 2023 - Springer
Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
Amino acids: Key sources for immunometabolites and immunotransmitters
M Miyajima - International Immunology, 2020 - academic.oup.com
Immune-cell activation and functional plasticity are closely linked to metabolic
reprogramming that is required to supply the energy and substrates for such dynamic …
reprogramming that is required to supply the energy and substrates for such dynamic …
Amino acid auxotrophy as a system of immunological control nodes
PJ Murray - Nature immunology, 2016 - nature.com
Cells of the immune system are auxotrophs for most amino acids, including several
nonessential ones. Arginine and tryptophan are used within the regulatory immune networks …
nonessential ones. Arginine and tryptophan are used within the regulatory immune networks …
Amino acid catabolism: an overlooked area of metabolism
N Torres, S Tobón-Cornejo, LA Velazquez-Villegas… - Nutrients, 2023 - mdpi.com
Amino acids have been extensively studied in nutrition, mainly as key elements for
maintaining optimal protein synthesis in the body as well as precursors of various nitrogen …
maintaining optimal protein synthesis in the body as well as precursors of various nitrogen …
Amino Acid Sensing via General Control Nonderepressible-2 Kinase and Immunological Programming
Metabolic adaptation to the changing nutrient levels in the cellular microenvironment plays a
decisive role in the maintenance of homeostasis. Eukaryotic cells are equipped with nutrient …
decisive role in the maintenance of homeostasis. Eukaryotic cells are equipped with nutrient …