Enhanced amino acid catabolism is a common response to inflammation, but the
immunologic significance of altered amino acid consumption remains unclear. The finding …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

The interaction between pathogenic microorganisms and their hosts is regulated by
reciprocal survival strategies, including competition for essential nutrients. Though …

Immune activation is now understood to be fundamentally linked to intrinsic and/or extrinsic
metabolic processes which are essential for immune cells to survive, proliferate, and perform …

Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

Immune-cell activation and functional plasticity are closely linked to metabolic
reprogramming that is required to supply the energy and substrates for such dynamic …

Cells of the immune system are auxotrophs for most amino acids, including several
nonessential ones. Arginine and tryptophan are used within the regulatory immune networks …

Metabolic adaptation to the changing nutrient levels in the cellular microenvironment plays a
decisive role in the maintenance of homeostasis. Eukaryotic cells are equipped with nutrient …

A growing body of evidence indicates that, over the course of evolution of the immune
system, arginine has been selected as a node for the regulation of immune responses. An …

Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …