[HTML][HTML] Nano-Proteolysis Targeting Chimeras (Nano-PROTACs) in Cancer Therapy

Y Song, QQ Dong, YK Ni, XL Xu… - International Journal of …, 2024 - ncbi.nlm.nih.gov
Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that have the
capability to induce specific protein degradation. While playing a revolutionary role in …

Progress of proteolysis-targeting chimeras (PROTACs) delivery system in tumor treatment

L Fan, W Tong, A Wei, X Mu - International Journal of Biological …, 2024 - Elsevier
Proteolysis targeting chimeras (PROTACs) can use the intrinsic protein degradation system
in cells to degrade pathogenic target proteins, and are currently a revolutionary frontier of …

Recent advances in pro-PROTAC development to address on-target off-tumor toxicity

C Chen, Y Yang, Z Wang, H Li, C Dong… - Journal of Medicinal …, 2023 - ACS Publications
Proteolysis-targeting chimera (PROTAC) technology represents a novel and promising
modality for targeted protein degradation with transformative implications for the clinical …

[HTML][HTML] Targeted protein degradation: A promising approach for cancer treatment

MZI Khan, A Nazli, I Naz, D Khan, I Haq… - Journal of Pharmaceutical …, 2023 - Elsevier
Targeted protein degradation (TPD) is a promising approach that has the ability to address
disease-causing proteins. Compared to traditional inhibition, proteolysis targeting chimera …

Nano proteolysis targeting chimeras (PROTACs) with anti‐hook effect for tumor therapy

NY Zhang, DY Hou, XJ Hu, JX Liang… - Angewandte …, 2023 - Wiley Online Library
Proteolysis targeting chimera (PROTAC) is an emerging pharmacological modality with
innovated post‐translational protein degradation capabilities. However, off‐target induced …

Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation

Y Chen, I Tandon, W Heelan, Y Wang… - Chemical Society …, 2022 - pubs.rsc.org
Proteolysis Targeting Chimeras (PROTACs), an emerging therapeutic entity designed to
degrade target proteins by hijacking the ubiquitin–proteasome system, have the potential to …

Current strategies for improving limitations of proteolysis targeting chimeras

C Pu, S Wang, L Liu, Z Feng, H Zhang, Q Gong… - Chinese Chemical …, 2023 - Elsevier
Proteolysis targeting chimeras (PROTACs) are bifunctional degrader molecules via
hijacking the ubiquitin-proteasome system (UPS) to specifically eliminate targeted proteins …

Emerging Strategies in Proteolysis-Targeting Chimeras (PROTACs): Highlights from 2022

R Tamatam, D Shin - International Journal of Molecular Sciences, 2023 - mdpi.com
Targeted protein degradation (TPD) is a promising therapeutic modality that has garnered
attention in academic, industrial, and pharmaceutical research for treating diseases such as …

Potential of the nanoplatform and PROTAC interface to achieve targeted protein degradation through the Ubiquitin–Proteasome system

H Xie, C Zhang - European Journal of Medicinal Chemistry, 2024 - Elsevier
In eukaryotic cells, the ubiquitin–proteasome system (UPS) plays a crucial role in selectively
breaking down specific proteins. The ability of the UPS to target proteins effectively and …

Target protein degradation by protacs: A budding cancer treatment strategy

D Choudhary, A Kaur, P Singh, G Chaudhary… - Pharmacology & …, 2023 - Elsevier
Cancer is one of the most common causes of death. So, its lethal effect increases with time.
Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or …