Aging is by far the most prominent risk factor for Alzheimer's disease (AD), and both aging
and AD are associated with apparent metabolic alterations. As developing effective …

Alzheimer's is a neurodegenerative disease with a complex and progressive pathological
phenotype characterized first by hypometabolism and impaired mitochondrial bioenergetics …

Significance: Alzheimer's disease (AD) is the leading cause of dementia. Thus far, 99.6% of
clinical trials, including those targeting energy metabolism, have failed to exert disease …

The complexities that underlie the cognitive impairment and neurodegeneration
characteristic of Alzheimer's disease (AD) have yet to be completely understood, although …

Abstract Purpose of Review Mitochondria are essential for facilitating energy homeostasis
under ever-changing environmental conditions. Mitochondrial dysfunction has been …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease and has become a
major socioeconomic issue in many developed countries. Currently available therapeutic …

Alzheimer's disease (AD) has a complex and progressive neurodegenerative phenotype,
with hypometabolism and impaired mitochondrial bioenergetics among the earliest …

Alzheimer's disease (AD) is an increasingly pressing worldwide public-health, social,
political and economic concern. Despite significant investment in multiple traditional …

Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

A decline in mitochondrial function plays a key role in the aging process and increases the
incidence of age-related disorders, including Alzheimer disease (AD). Mitochondria—the …