Histone demethylase KDM2A: Biological functions and clinical values
L Liu, J Liu, Q Lin - Experimental and Therapeutic …, 2021 - spandidos-publications.com
Histone lysine demethylation modification is a critical epigenetic modification. Lysine
demethylase 2A (KDM2A), a Jumonji C domain‑containing demethylase, demethylates the …
demethylase 2A (KDM2A), a Jumonji C domain‑containing demethylase, demethylates the …
[HTML][HTML] The critical role of histone lysine demethylase KDM2B in cancer
M Yan, X Yang, H Wang, Q Shao - American journal of …, 2018 - ncbi.nlm.nih.gov
The discovery of histone demethylases has revealed the dynamic nature of the regulation of
histone methylation. KDM2B is an important histone lysine demethylase that removes methyl …
histone methylation. KDM2B is an important histone lysine demethylase that removes methyl …
Advances in histone demethylase KDM3A as a cancer therapeutic target
J Yoo, YH Jeon, HY Cho, SW Lee, GW Kim, DH Lee… - Cancers, 2020 - mdpi.com
Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …
The role of the histone demethylase KDM4A in cancer
L Guerra-Calderas, R González-Barrios, LA Herrera… - Cancer genetics, 2015 - Elsevier
Histone posttranslational modifications are important components of epigenetic regulation.
One extensively studied modification is the methylation of lysine residues. These …
One extensively studied modification is the methylation of lysine residues. These …
The diverse roles of histone demethylase KDM4B in normal and cancer development and progression
Z Wang, H Cai, E Zhao, H Cui - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Histone methylation status is an important process associated with cell growth, survival,
differentiation and gene expression in human diseases. As a member of the KDM4 family …
differentiation and gene expression in human diseases. As a member of the KDM4 family …
Extended recognition of the histone H3 tail by histone demethylase KDM5A
Human lysine demethylase KDM5A is a chromatin-modifying enzyme associated with
transcriptional regulation, because of its ability to catalyze removal of methyl groups from …
transcriptional regulation, because of its ability to catalyze removal of methyl groups from …
Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis
J Yoo, GW Kim, YH Jeon, JY Kim, SW Lee… - … & Molecular Medicine, 2022 - nature.com
Distinct epigenetic modifiers ensure coordinated control over genes that govern a myriad of
cellular processes. Growing evidence shows that dynamic regulation of histone methylation …
cellular processes. Growing evidence shows that dynamic regulation of histone methylation …
Advances in histone demethylase KDM4 as cancer therapeutic targets
DH Lee, GW Kim, YH Jeon, J Yoo, SW Lee… - The FASEB …, 2020 - Wiley Online Library
Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …
[HTML][HTML] Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential
RM Labbé, A Holowatyj, ZQ Yang - American journal of …, 2014 - ncbi.nlm.nih.gov
KDM4 histone demethylases catalyze the removal of methyl marks from histone lysine
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway
S Hayami, M Yoshimatsu, A Veerakumarasivam… - Molecular cancer, 2010 - Springer
Background Although an increasing number of histone demethylases have been identified
and biochemically characterized, their biological functions largely remain uncharacterized …
and biochemically characterized, their biological functions largely remain uncharacterized …