Type III interferons: emerging roles in autoimmunity
S Manivasagam, RS Klein - Frontiers in immunology, 2021 - frontiersin.org
Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines
that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs …
that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs …
Interferon (IFN)-λ takes the helm: immunomodulatory roles of type III IFNs
Type III interferons (IFNs)(or IFN-λ) are the latest addition to the IFN family. Even though they
share little protein homology with type I IFN, both exhibit remarkable functional similarities …
share little protein homology with type I IFN, both exhibit remarkable functional similarities …
Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control
Highlights•IFNλs are dual function cytokines mediating antiviral activity and damage
control.•IFNλs confer initial antimicrobial protection at anatomical barriers without provoking …
control.•IFNλs confer initial antimicrobial protection at anatomical barriers without provoking …
Context is key: delineating the unique functions of IFNα and IFNβ in disease
LE Fox, MC Locke, DJ Lenschow - Frontiers in immunology, 2020 - frontiersin.org
Type I interferons (IFNs) are critical effector cytokines of the immune system and were
originally known for their important role in protecting against viral infections; however, they …
originally known for their important role in protecting against viral infections; however, they …
Type III interferons (IFNs): emerging master regulators of immunity
IE Galani, O Koltsida, E Andreakos - Crossroads between innate and …, 2015 - Springer
Lambda interferons (IFN-λs), type III interferons or interleukins 28 and 29 are the latest
addition to the class II cytokine family. They share low homology with the interferon (IFN) and …
addition to the class II cytokine family. They share low homology with the interferon (IFN) and …
Shared and distinct functions of type I and type III interferons
Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …
including induction by viral infection, activation of shared signaling pathways, and …
Interferon-λs: front-line guardians of immunity and homeostasis in the respiratory tract
Type III interferons (IFNs), also termed lambda IFNs (IFNλs) or interleukins-28/29, constitute
a new addition to the IFN family. They are induced upon infection and are particularly …
a new addition to the IFN family. They are induced upon infection and are particularly …
Lambda interferons in immunity and autoimmunity
S Vlachiotis, E Andreakos - Journal of Autoimmunity, 2019 - Elsevier
Type I IFNs are well known players in immunity and autoimmunity. They induce potent
innate and adaptive immune responses essential for mediating host defenses against viral …
innate and adaptive immune responses essential for mediating host defenses against viral …
Functions of IFNλs in anti-bacterial immunity at mucosal barriers
N Alphonse, RE Dickenson, A Alrehaili… - Frontiers in …, 2022 - frontiersin.org
Type III interferons (IFNs), or IFNλs, are cytokines produced in response to microbial ligands.
They signal through the IFNλ receptor complex (IFNLR), which is located on epithelial cells …
They signal through the IFNλ receptor complex (IFNLR), which is located on epithelial cells …
Confounding roles for type I interferons during bacterial and viral pathogenesis
JA Carrero - International immunology, 2013 - academic.oup.com
Although type I interferons (IFN-I) were initially defined as potent antiviral agents, they can
also cause decreased host resistance to some bacterial and viral infections. The many …
also cause decreased host resistance to some bacterial and viral infections. The many …