On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome
BJE Lyons, NCJ Strynadka - Medchemcomm, 2019 - pubs.rsc.org
The type III secretion system injectisome is a syringe-like multimembrane spanning
nanomachine that is essential to the pathogenicity but not viability of many clinically relevant …
nanomachine that is essential to the pathogenicity but not viability of many clinically relevant …
[HTML][HTML] Recent structural advances towards understanding of the bacterial type III secretion injectisome
J Jenkins, LJ Worrall, NCJ Strynadka - Trends in Biochemical Sciences, 2022 - cell.com
The bacterial injectisome is a structurally conserved, syringe-shaped nanomachine that
spans the Gram-negative envelope and forms a continuous channel for type III secretion of …
spans the Gram-negative envelope and forms a continuous channel for type III secretion of …
T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly
The bacterial injectisome is a syringe-shaped macromolecular nanomachine utilized by
many pathogenic Gram-negative bacteria, including the causative agents of plague, typhoid …
many pathogenic Gram-negative bacteria, including the causative agents of plague, typhoid …
Structural control for the coordinated assembly into functional pathogenic type-3 secretion systems
N Goessweiner-Mohr, V Kotov, MJ Brunner, J Mayr… - biorxiv, 2019 - biorxiv.org
Functional injectisomes of the type-3 secretion system assemble into highly defined and
stoichiometric bacterial molecular machines essential for infecting human and other …
stoichiometric bacterial molecular machines essential for infecting human and other …
Piecing together the type III injectisome of bacterial pathogens
TF Moraes, T Spreter, NCJ Strynadka - Current opinion in structural biology, 2008 - Elsevier
The Type III secretion system is a bacterial 'injectisome'which allows Gram-negative bacteria
to shuttle virulence proteins directly into the host cells they infect. This macromolecular …
to shuttle virulence proteins directly into the host cells they infect. This macromolecular …
Structural overview of the bacterial injectisome
LJ Worrall, E Lameignere, NCJ Strynadka - Current opinion in microbiology, 2011 - Elsevier
The bacterial injectisome is a specialized protein-export system utilized by many pathogenic
Gram-negative bacteria for the delivery of virulence proteins into the hosts they infect. This …
Gram-negative bacteria for the delivery of virulence proteins into the hosts they infect. This …
Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injectisome
Type III secretion systems are multiprotein molecular machines required for the virulence of
several important bacterial pathogens. The central element of these machines is the …
several important bacterial pathogens. The central element of these machines is the …
[HTML][HTML] Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin
The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …
Investigating the assembly of the bacterial type III secretion system injectisome by in vivo photocrosslinking
N Singh, S Wagner - International Journal of Medical Microbiology, 2019 - Elsevier
Virulence-associated type III secretion systems serve the injection of bacterial effector
proteins into eukaryotic host cells. These effector proteins modulate host cell biology in order …
proteins into eukaryotic host cells. These effector proteins modulate host cell biology in order …
The type III secretion injectisome
GR Cornelis - Nature Reviews Microbiology, 2006 - nature.com
The type III secretion injectisome is a complex nanomachine that allows bacteria to deliver
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …