Developing predictive biomarkers that can detect the tipping point before metastasis of
hepatocellular carcinoma (HCC), is critical to prevent further irreversible deterioration. To …

Comprehensive molecular analyses of metastatic hepatocellular carcinoma (HCC) are
lacking. Here, we generate multi-omic profiling of 257 primary and 176 metastatic regions …

Hepatocellular carcinoma (HCC) is one of the most common fatal malignancies but the
molecular genetic basis of this disease remains unclear. By using genome-wide methylation …

Background Liver hepatocellular carcinoma (LIHC) ranks sixth among the most common
types of cancer with a high mortality rate. Cuproptosis is a newly discovered type of cell …

Location-associated long noncoding RNA (lncRNA) was reported to interact with target
protein via a cis-regulatory process especially for the Flank10kb class lncRNA. Based on …

Chronic infections with the hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major
risks of hepatocellular carcinoma (HCC), and great efforts have been made towards the …

Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and
heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs …

The occurrence of hepatocellular carcinoma (HCC) related to liver cirrhosis is mostly
accompanied by extensive immune infiltration. To reveal the infiltration immune cells …

Intratumor heterogeneity may result from the evolution of tumor cells and their continuous
interactions with the tumor microenvironment which collectively drives tumorigenesis …

Tumor lineage plasticity is emerging as a critical mechanism of therapeutic resistance and
tumor relapse. Highly plastic tumor cells can undergo phenotypic switching to a drug …