A recent study by Adams and colleagues published in Nature unveiled more than one
hundred genes that are involved in micronucleus formation, 1 which is a biomarker for …

Genomic instability arising from defective responses to DNA damage or mitotic
chromosomal imbalances can lead to the sequestration of DNA in aberrant extranuclear …

Genome instability (GIN) is a main contributing factor to congenital and somatic diseases,
but its sporadic occurrence in individual cell cycles makes it difficult to study mechanistically …

Chromosome-containing micronuclei are a feature of human cancer. Micronuclei arise from
chromosome mis-segregation and characterize tumors with elevated rates of chromosomal …

Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …

Micronuclei (MN) are cytosolic bodies that sequester acentric fragments or mis-segregated
chromosomes from the primary nucleus. Spontaneous rupture of the MN envelope allows …

Aneuploidy is a hallmark of cancer and underlies genetic disorders characterized by severe
developmental defects, yet the molecular mechanisms explaining its effects on cellular …

Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced
and metastatic cancers [-], yet whether they are mechanistically linked is unknown. Here we …

Two recent studies by Bui and Butin-Israeli et al. have established the novel contribution of
neutrophils to genomic instability induction and aberrant shaping of the DNA repair …

Micronuclei are aberrant nuclear compartments that trap a portion of a cell's chromatin in a
distinct organelle separate from the nucleus and are drivers of inflammation, DNA damage …