The tumor suppressor p53 is an important cellular protein, which controls cell cycle
progression. Phosphorylation is one of the mechanisms by which p53 is regulated. Here we …

The p53 transcriptional network orchestrates alternative stress responses such as cell-cycle
arrest and apoptosis. Here we investigate the mechanism of differential expression of p21, a …

Abstract Cyclin dependent kinase 5 (Cdk5) is a proline‐direct protein kinase that is most
active in the CNS, and has been implicated as a contributing factor in certain …

Tumor formation is a multistep process during which cells acquire genetic and epigenetic
changes until they reach a fully transformed state. We show that CDK6 contributes to tumor …

Tumor suppressor p53 is often activated in response to DNA damage or otherforms of stress,
leading to either cell cycle arrest or apoptosis. Stress-induced kinasesphosphorylate p53 …

Cell cycle arrest in response to DNA damage involves protein stabilization and consequent
upregulation of p53, which induces transcription of cyclin-dependent kinase inhibitor p21 …

Abstract Cyclin-dependent kinase 5 (Cdk5) is a member of the cyclin-dependent kinase
family that is mostly seen in neurons, does not vary with cell cycle, and is activated in many …

The tumor suppressor protein p53 plays a central role in the induction of apoptosis in
response to genotoxic stress. The protein kinase Chk2 is an important regulator of p53 …

Cdk7, the CDK-activating kinase and transcription factor IIH component, is a target of
inhibitors that kill cancer cells by exploiting tumor-specific transcriptional dependencies …

Background p53 is the most studied tumor suppressor and its overexpression may or may
not cause cell death depending upon the genetic background of the cells. p53 is degraded …