Introduction: To quantitatively investigate sources of inter-& intra-individual variability of
inhaled delivery of drugs to the lungs, we describe here a novel modelling and simulation …

A key issue in pulmonary drug delivery is improving the medical delivery device for effective
and targeted treatment. Spacers are clear plastic containers attached to inhalers aimed at …

The magnitude and regional heterogeneity of airway obstructions in severe asthmatics is
likely linked to insufficient drug delivery, as evidenced by the inability to mitigate …

Laminar-to-turbulent air flow for typical inhalation modes as well as micro-particle transport
and wall deposition in a representative human oral airway model have been simulated …

The influences of the profiles and cross-sectional areas of glottal aperture on the upper
respiratory airway are investigated using an idealized cast-based mouth-throat model and …

Background Understanding respiratory physiology can aid clinicians in diagnosing the
cause of respiratory symptoms or shed light on drug delivery inhaler device optimisation …

An excellent understanding of the airflow structures is critical to enhance the efficiency of
drug delivery via the human oral airway. The present paper investigates the characteristics …

Most numerical studies of airflow resistance in the lungs have presented flow dynamics in
different stenosis tracheobronchial airway generations. However, not much is known about …

Patients referred for treatment of tracheal stenosis typically are asymptomatic until critical
narrowing of the airway occurs, which then requires immediate intervention. To understand …

A representative human upper respiratory tract (URT) with idealized oral region and
asymmetric tracheobronchial (TB) airway has been modeled, and laminar-to-turbulent …