The recent recognition of the sleep apnea syndrome has forced a re-evaluation of the
mechanism of hypercapnia and disordered respiratory control in obese patients. Thirteen …

Eight adult patients with sleep apnea were studied to evaluate the ventilatory and cardiac
effects of hyperoxia on an acute basis. Five patients then used low-flow nighttime oxygen for …

We have observed patients who clinically have the obstructive sleep apnea syndrome but
have no apneas, instead having recurrent nocturnal hypoventilation. There is disagreement …

To define the pathogenesis of apneas, eight patients with hypersomnia-sleep apnea
syndrome were studied during nocturnal sleep. Diaphragmatic and genioglossal elec …

During the past decade, it has become evident not only that sleep itself but also different
sleep states may have a marked effect on breathing. Sleep may reveal an abnormality of air …

Four morbidly obese men who had been found to have significant sleep-disordered
breathing and oxygen desaturation were restudied after an average weight loss of 108 kg …

The mechanisms of hypercapnia in eight patients with the “Pickwickian” syndrome and
obstructive sleep apnea (OSAS) were evaluated pretherapy and posttherapy (tracheostomy …

The possible role of ventilatory control in relation to sleep apnea has not yet been clarified.
We investigated the relationship between awake ventilatory drives to hypoxia and …

In order to determine the relationship between chronic hypercapnia and anthropomorphic
data, pulmonary function tests and slopes of ventilatory responses to hypercapnia (HVCR) …

The mechanisms responsible for the development of chronic hypercapnia in patients with
obstructive sleep apnea (OSA) are not well defined. Therefore, we tested the hypothesis that …