Multiple M yeloma (MM), a malignancy of plasma cells, remains incurable despite the use of
conventional and novel therapies. Halofuginone (HF), a synthetic derivative of …

Halofuginone has recently been shown to inhibit tumor progression of various types of
cancers. The antitumoral effect was associated with decreased tumor angiogenesis rather …

Promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) expression in acute
promyelocytic leukemia (APL) impairs transforming growth factor beta (TGFβ) signaling …

PURPOSE: Halofuginone (tempostatin™) is a synthetic derivative of a quinazolinone
alkaloid showing anti-angiogenic, anti-metastatic and anti-proliferative effects in preclinical …

Purpose: Halofuginone (HF) inhibits synthesis of collagen type I and matrix
metalloproteinase-2 and is being considered for clinical evaluation as an antineoplastic …

Since a variety of cell intrinsic and extrinsic molecular abnormalities cooperatively promote
tumor formation in multiple myeloma (MM), therapeutic approaches that concomitantly target …

Homoharringtonine (HHT) is a known anti-leukemia drug that inhibits multiple myeloma
(MM) cells both in vitro and in vivo. Our prior study demonstrated that the potency of HHT in …

Abstract STUDY QUESTION Does halofuginone (HF) inhibit the growth of human uterine
leiomyoma cells in a mouse xenograft model? SUMMARY ANSWER HF suppresses the …

Background Halofuginone (HF) is a low-molecular-weight alkaloid that has been
demonstrated to interfere with Metalloproteinase-2 (MMP-2) and Tumor Growth Factor-β …

Simple Summary Multiple myeloma (MM) is a cancer of white blood cells known as plasma
cells. It is hard to treat cancer, thus requires new treatments. Herein, a plant extracted …