Serotonin in the gut: Blessing or a curse

S Banskota, JE Ghia, WI Khan - Biochimie, 2019 - Elsevier
Abstract Serotonin (5-hydroxytryptamine or 5-HT) once most extensively studied as a
neurotransmitter of the central nervous system, is seen to be predominantly secreted in the …

Role of serotonin in gastrointestinal physiology and pathology.

C Cirillo, V Berghe, J Tack - Minerva endocrinologica, 2011 - europepmc.org
Serotonin is one of the most abundant molecules in the gastrointestinal tract and it plays a
crucial role in the regulation of several physiological functions, such as motility, secretion …

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

GM Mawe, JM Hoffman - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Abstract Serotonin (5-HT) has been recognized for decades as an important signalling
molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT …

Gut-derived serotonin and its emerging roles in immune function, inflammation, metabolism and the gut–brain axis

S Banskota, WI Khan - Current Opinion in Endocrinology …, 2022 - journals.lww.com
Emerging evidence regarding the role of peripheral 5-HT in the regulation of various
physiological and pathophysiological conditions opens up new targets for researchers to …

The multifaceted role of serotonin in intestinal homeostasis

N Koopman, D Katsavelis, AS Ten Hove, S Brul… - International journal of …, 2021 - mdpi.com
The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with
conserved production in prokaryotes and eukaryotes and a wide range of functions. In the …

the many potential roles of intestinal serotonin (5‐hydroxytryptamine, 5‐HT) signalling in inflammatory bowel disease

MD Coates, I Tekin, KE Vrana… - Alimentary …, 2017 - Wiley Online Library
Summary Background Serotonin (5‐hydroxytryptamine, 5‐HT) is an important mediator of
every major gut‐related function. Recent investigations also suggest that 5‐HT can influence …

Non-conventional features of peripheral serotonin signalling—the gut and beyond

SN Spohn, GM Mawe - Nature reviews Gastroenterology & hepatology, 2017 - nature.com
Serotonin was first discovered in the gut, and its conventional actions as an intercellular
signalling molecule in the intrinsic and extrinsic enteric reflexes are well recognized, as are …

The role of serotonin and its receptors in activation of immune responses and inflammation

MS Shajib, WI Khan - Acta physiologica, 2015 - Wiley Online Library
Abstract Serotonin or 5‐hydroxytryptamine (5‐HT) is a neurotransmitter and hormone that
contributes to the regulation of various physiological functions by its actions in the central …

The mechanism of secretion and metabolism of gut-derived 5-hydroxytryptamine

N Liu, S Sun, P Wang, Y Sun, Q Hu… - International journal of …, 2021 - mdpi.com
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a metabolite of tryptophan and is
reported to modulate the development and neurogenesis of the enteric nervous system, gut …

The diverse metabolic roles of peripheral serotonin

AM Martin, RL Young, L Leong, GB Rogers… - …, 2017 - academic.oup.com
Abstract Serotonin (5-hydroxytryptamine or 5-HT) is a multifunctional bioamine with
important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our …