A pharmacological and clinical overview of oral semaglutide for the treatment of type 2 diabetes

A Andersen, FK Knop, T Vilsbøll - Drugs, 2021 - Springer
Oral semaglutide (Rybelsus®) is a glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-
1RA) with 94% homology to human GLP-1. It is the first GLP-1RA developed for oral …

[HTML][HTML] Semaglutide: review and place in therapy for adults with type 2 diabetes

RM Goldenberg, O Steen - Canadian journal of diabetes, 2019 - Elsevier
Guidelines increasingly highlight the importance of multifactorial management in type 2
diabetes, in contrast to the more traditional focus on glycemic control. Semaglutide, a …

Safety and tolerability of semaglutide across the SUSTAIN and PIONEER phase IIIa clinical trial programmes

VR Aroda, U Erhan, P Jelnes, JJ Meier… - Diabetes, Obesity …, 2023 - Wiley Online Library
Aim Glucagon‐like peptide‐1 receptor agonists improve glycaemic control: some are now
available as oral and subcutaneous formulations, and some have indications for reducing …

Pharmacokinetics and clinical implications of semaglutide: a new glucagon-like peptide (GLP)-1 receptor agonist

S Hall, D Isaacs, JN Clements - Clinical pharmacokinetics, 2018 - Springer
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) came to market in the year 2005, as
a new therapeutic classification, for clinical use in the management of type 2 diabetes …

Oral semaglutide in the management of type 2 diabetes: a report on the evidence to date

S Pearson, N Kietsiriroje, RA Ajjan - Diabetes, metabolic syndrome …, 2019 - Taylor & Francis
In recent years, newer drug classes for the treatment of type 2 diabetes mellitus have been
released with significant effects on glucose lowering and weight reduction. One of the most …

Oral semaglutide in type 2 diabetes

SL Anderson, TR Beutel, JM Trujillo - Journal of Diabetes and its …, 2020 - Elsevier
Background Previously, the only available glucagon-like peptide-1 receptor agonists (GLP-1
RA) were injectable. Approval of oral semaglutide (Rybelsus®) represents the first orally …

Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: insights from the …

VR Aroda, A Ahmann, B Cariou, F Chow… - Diabetes & …, 2019 - Elsevier
In individuals with type 2 diabetes, glycaemic control and cardiovascular risk factor
management reduces the likelihood of late-stage diabetic complications. Guidelines …

Efficacy, safety and cardiovascular outcomes of once‐daily oral semaglutide in patients with type 2 diabetes: the PIONEER programme

TK Thethi, R Pratley, JJ Meier - Diabetes, Obesity and …, 2020 - Wiley Online Library
Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are recommended for glycaemic
management in patients with type 2 diabetes (T2D). Oral semaglutide, the first oral GLP …

Oral semaglutide for the treatment of type 2 diabetes

MS Hedrington, SN Davis - Expert opinion on pharmacotherapy, 2019 - Taylor & Francis
ABSTRACT Introduction: Glucagon-like peptide-1 (GLP-1) receptor agonists are highly
potent antihyperglycemic drugs that impose low risk of hypoglycemia and also result in body …

[HTML][HTML] The efficacy and safety of oral semaglutide for glycaemic management in adults with type 2 diabetes compared to subcutaneous semaglutide, placebo, and …

Y Alhindi, A Avery - Contemporary clinical trials communications, 2022 - Elsevier
Aim Semaglutide is a long-acting glucagon-like peptide-1 receptor agonist (GLP-1 RA)
indicated for glycaemic management in adults with type 2 diabetes (T2D). Oral semaglutide …