Aims To investigate the frequency of the single nucleotide polymorphism C3435T in exon 26
of the MDR1 gene in Asians and to determine the functional significance of this SNP with the …

Abstract P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as
an energy-dependent efflux pump that exports its substrates out of the cell. PGP expression …

Results: The genotype frequencies were: CC 32%(n= 85), CT 48%(n= 127) and TT 20%(n=
53). C and T allele frequencies were 0.56 and 0.44 respectively. The C allelic frequency for …

P-glycoprotein (P-gp), the protein product of MDR1 gene, is an important factor regulating
the bioavailability of many therapeutics. Recently, the C3435T polymorphism of MDR1 was …

Two representative genetic variants of the MDR1 gene, 3435C> T and 2677G> T/A, show
wide interethnic differences in its genetic polymorphism. In this study, the authors evaluated …

To determine the relationship between C3435T mutation in exon 26 of the human multidrug
resistant 1 (MDR1) gene and cyclosporine pharmacokinetic parameters among healthy …

P-glycoprotein (PGP) is a transmembrane efflux transporter with an important role in drug
therapy. The level of PGP expression leads to relevant consequences in terms of efficacy …

The published data revealed conflicting results of the polymorphism of MDR1 exon 26 SNP
C3435T on the pharmacokinetics of cyclosporine; thus, the aim was to conduct a meta …

BACKGROUND: Single nucleotide polymorphisms (SNPs) in the multidrug resistance
(MDR1) gene correlate with the intestinal function of P-glycoprotein (PGP). PGP serves as a …

Background. Cyclosporine A (CsA) is characterized by high interindividual variations in oral
bioavailability and a narrow therapeutic index. CsA is a substrate for P-glycoprotein, a …