There is an increasing interest in detecting genes, or genomic regions, that have been
targeted by natural selection. The interest stems from a basic desire to learn more about …

Clues to our evolutionary history lie hidden within DNA sequence data. One of the great
challenges facing population geneticists is to identify and accurately interpret these clues …

The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …

Rapid and inexpensive sequencing technologies are making it possible to collect whole
genome sequence data on multiple individuals from a population. This type of data can be …

Examining genomic data for traces of selection provides a powerful tool for identifying
genomic regions of functional importance. Many methods for identifying such regions have …

Population geneticists have long sought to understand the contribution of natural selection
to molecular evolution. A variety of approaches have been proposed that use population …

Abstract Changes in gene expression may represent an important mode of human
adaptation. However, to date, there are relatively few known examples in which selection …

Complete genome sequences contain valuable information about natural selection, but this
information is difficult to access for short, widely scattered noncoding elements such as …

Natural selection and demographic forces can have similar effects on patterns of DNA
polymorphism. Therefore, to infer selection from samples of DNA sequences, one must …

Teasing apart the effects of selection and demography on genetic polymorphism remains
one of the major challenges in the analysis of population genomic data. The traditional …