The medial prefrontal cortex (mPFC) has been implicated in the development of behavioral
sensitization, which is the progressive enhancement of locomotor activity that occurs with …

It has been postulated that behavioral sensitization to cocaine is associated with an
attenuation of cocaine-induced dopamine (DA) transmission in the medial prefrontal cortex …

Previous data suggest that cocaine‐induced dopamine (DA) transmission within the medial
prefrontal cortex (mPFC) undergoes time‐dependent changes during withdrawal from …

Repeated administration of cocaine progressively increases drug-induced locomotor
activity. This study examined the role of dopamine D1-and D2-like receptors in the medial …

Male Sprague-Dawley rats that were naive or that had been treated with five daily saline or
cocaine injections (15 mg/kg ip) were subsequently challenged with an injection of cocaine …

We examined the role of the dopamine projection to the medial prefrontal cortex in
amphetamine-induced sensitization of meso-nucleus accumbens dopamine function. In the …

J. Neurochem.(2011) 119, 332–341. Abstract Repeated exposure to cocaine progressively
increases drug‐induced locomotor activity, which is termed behavioral sensitization …

Extracellular levels of dopamine are increased in response to systemic administration of
cocaine in several brain areas including the nucleus accumbens and medial prefrontal …

Rationale Recent studies have suggested that the medial prefrontal cortex (mPFC) plays an
important role in the development of sensitization to cocaine. In particular, a recent report …

Studies support the involvement of mPFC dopaminergic and glutamatergic systems in the
development of cocaine sensitization. GABA is known to modulate dopamine and …