Aquaporins: role in cerebral edema and brain water balance
The regulation of water balance in the brain is crucial. A disruption in this equilibrium causes
an increase in brain water content that significantly contributes to the pathophysiology of …
an increase in brain water content that significantly contributes to the pathophysiology of …
Aquaporin water channels and hydrocephalus
AS Verkman, L Tradtrantip, AJ Smith, X Yao - Pediatric Neurosurgery, 2017 - karger.com
The aquaporins (AQPs) are a family of water-transporting proteins that are broadly
expressed in mammalian cells. Two AQPs in the central nervous system, AQP1 and AQP4 …
expressed in mammalian cells. Two AQPs in the central nervous system, AQP1 and AQP4 …
Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin‐4 water channels
The glial water channel aquaporin‐4 (AQP4) has been hypothesized to modulate water and
potassium fluxes associated with neuronal activity. In this study, we examined the seizure …
potassium fluxes associated with neuronal activity. In this study, we examined the seizure …
Localization of aquaporin 1 water channel in the Schmidt–Lanterman incisures and the paranodal regions of the rat sciatic nerve
E Segura-Anaya, A Martínez-Gómez, MAR Dent - Neuroscience, 2015 - Elsevier
Abstract Aquaporin 1 (AQP1) is a member of a family of small, integral membrane water-
transporting proteins, which facilitate water movement across cell membranes in response to …
transporting proteins, which facilitate water movement across cell membranes in response to …
Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones.
BK Tamarappoo, AS Verkman - The Journal of clinical …, 1998 - Am Soc Clin Investig
Five single-point aquaporin-2 (AQP2) mutations that cause non-X-linked nephrogenic
diabetes insipidus (NDI) were characterized to establish the cellular defect and to develop …
diabetes insipidus (NDI) were characterized to establish the cellular defect and to develop …
Heterogeneous occurrence of aquaporin-4 in the ependyma and in the circumventricular organs in rat and chicken
O Goren, I Adorján, M Kálmán - Anatomy and embryology, 2006 - Springer
Aquaporins are selective water channel proteins critical in volume homeostasis. In the CNS
AQP4 predominates, localized mainly in the glia limitans, the perivascular endfeet and …
AQP4 predominates, localized mainly in the glia limitans, the perivascular endfeet and …
Aquaporin 4: lack of mRNA expression in the rat regenerating muscle fiber under denervation
T Jimi, Y Wakayama, M Murahashi, S Shibuya… - Neuroscience …, 2000 - Elsevier
The recently identified water channel aquaporin 4 is a major component of the orthogonal
arrays observed with freeze-fracture electron microscopy. We examined the expression of …
arrays observed with freeze-fracture electron microscopy. We examined the expression of …
Aquaporins: translating bench research to human disease
AS Verkman - Journal of Experimental Biology, 2009 - journals.biologists.com
There is considerable potential for translating knowledge of aquaporin structure, function
and physiology to the clinic. One area is in aquaporin-based diagnostics. The discovery of …
and physiology to the clinic. One area is in aquaporin-based diagnostics. The discovery of …
Three-dimensional organization of the aquaporin water channel: What can structure tell us about function?
AK Mitra - 2001 - Elsevier
Publisher Summary The entry and exit of water across the lipid bilayer membrane is a
fundamental physiological process necessary for maintaining cell homeostasis, which is …
fundamental physiological process necessary for maintaining cell homeostasis, which is …