Pancreatic beta cells play a critical role in maintaining glucose homeostasis by serving as
the primary source of insulin. These cells are responsible for the synthesis, storage, and …

The primary function of pancreatic beta‐cells is to produce and release insulin in response
to increment in extracellular glucose concentrations, thus maintaining glucose homeostasis …

Diabetes is one of the leading causes of premature mortality worldwide and has become
one of the major health challenges of the 21st century. Diabetes develops when insulin …

Pancreatic β-cells produce and secrete insulin to maintain blood glucose levels within a
narrow range. Defects in the function and mass of β-cells play a significant role in the …

The pancreatic beta cell functions as a key regulator of blood glucose levels by integrating a
variety of signals in response to changing metabolic demands. Variations in beta cell identity …

Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …

Type 1 and type 2 diabetes are both diseases of insulin insufficiency, although they develop
by distinct pathways. The recent surge in the incidence of type 2 diabetes and the chronic …

Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …

Cell lineage development is a finely tuned process of proliferation and differentiation,
survival and apoptosis, that is regulated by numerous extracellular signals. Here we review …

In both type 1 and type 2 diabetes, insufficient numbers of insulin-producing β cells are a
major cause of defective control of blood glucose and its complications. Accordingly …