Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing
macromolecules deliver their payload selectively to solid tumors. An important driver of …

The enhanced permeability and retention (EPR) of nanoparticles in tumors has long stood
as one of the fundamental principles of cancer drug delivery, holding the promise of safe …

Interest of tumor targeting through EPR effect is still controversial due to intrinsic low
targeting efficacy and rare translation to human cancers. Moreover, due to different reasons …

Malignant tumor (cancer) remains as one of the deadliest diseases throughout the world,
despite its overall mortality drops. Nanomaterials (NMs) have been widely studied as …

Numerous nano drug delivery systems have been developed for preclinical cancer research
in the past 15 years with the hope for a fundamental change in oncology. The robust …

The enhanced permeability and retention (EPR) effect in human solid tumors is being
increasingly questioned due to the failure of many nanomedicines in their clinical …

Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

Nanomedicines including liposomes, micelles, and nanoparticles based on the enhanced
permeability and retention (EPR) effect have become the mainstream for tumor treatment …

Over recent years, advancements in nanomedicine have allowed new approaches to
diagnose and treat tumors. Nano drug delivery systems exploit the enhanced permeability …

Background In past few decades, the research on engineered nanocarriers (NCs) has
gained significant attention in cancer therapy due to selective delivery of drug molecules on …