Accumulation of reactive oxygen species (ROS) induced by oxidative stress (OS) affects cell
survival, cell function and even results in cell death. As a major transcription factor of …

It is a great challenge to develop a safe and effective treatment strategy for age-related
osteoporosis and fracture healing. As one of the four FOXO transcription factors, FOXO1 is …

Several mechanisms contribute to the decline of all physiologic functions during aging. As a
consequence, disease incidence increases with age. Central to this multifactorial process is …

Osteoporosis, a disease of low bone mass, is associated with decreased osteoblast
numbers and increased levels of oxidative stress within osteoblasts. Since transcription …

Aging increases oxidative stress and osteoblast apoptosis and decreases bone mass,
whereas forkhead box O (FoxO) transcription factors defend against oxidative stress by …

FOXO transcription factors especially FOXO1 have profound roles in bone development and
remodeling. The regulation of cells of the osteoblast lineage by FOXOs is suggested to be …

Decline of antioxidant defense after estrogen deficiency leads to oxidative damage in bone
marrow-derived mesenchymal stem cells (BMMSCs), resulting a defect of bone formation in …

Uncontrolled oxidative stress impairs bone formation and induces age‐related bone loss in
humans. The FoxO family is widely accepted to play an important role in protecting diverse …

Forkhead box O1 (FOXO1) is upregulated during bone formation and in response to
stimulation by bone morphogenetic proteins. Studies presented here examined the …

The FoxO subfamily of forkhead transcription factors plays a critical role in a variety of
physiological processes including metabolism, differentiation, proliferation, apoptosis and …