Endothelin has been shown to suppress increased vascular permeability in the rat at doses
of 0.01 pmol. The agonists used were nitric oxide and nitroprusside, which have the same …

ABSTRACT Endothelin(ET)-1 is a potent vasoactive peptide elaborated by the vascular
endothelial cells. In the present study we examined the effects of ischemia-hypoxia(I/H) on …

✓ Oxyhemoglobin and endothelin have both been linked to the development of the severe
and sustained cerebral vasospasm associated with subarachnoid hemorrhage. The effects …

The potent vasoconstrictor endothelin-1 (ET-1) is a paracrine, but also autocrine, factor for
some types of cells. The goal of our study was to evaluate whether the receptor population in …

A permanent vascular endothelial cell line, EA. hy 926, was shown to express endothelin-1
(ET-1) mRNA and to secrete big ET-1 and ET-1 into culture medium. The concentration of …

ABSTRACT Endothelin-1(ET-1) caused a dose-dependent vasoconstnction in rat aortic
strips in vitro. The sensitivity to ET-1 was significantly higher in 12-week-old spontaneously …

Endothelin (ET-1), a potent vasoconstrictor peptide, has been isolated from the conditioned
culture medium of porcine aortic endothelial cells and its structure sequenced (Yanagisawa …

Endothelial cells lining the lumen of blood vessels participate actively in the regulation of the
tone of the underlying smooth muscle (eg Furchgott 1983; Vanhoutte et al. 1986; Ignarro …

Modulation of the biosynthesis of the vasoconstrictor peptide endothelin was studied in
cultured endothelial cells. Immunoreactive endothelin (irET) levels were significantly …

One of the major biological effects of the endothelium-derived peptide endothelin-1 (ET-1) is
its receptor-mediated constrictive action on vascular smooth muscle. In this study, we have …