Using front-surface fluorometry and fura-2-loaded porcine coronary arterial strips with an
intact endothelium, changes in cytosolic Ca 2+ concentrations ([Ca 2+] i) and tension of …

Abstract Endothelin-1 (ET-1), a peptide product of endothelial cells, is mitogenic for
fibroblasts and smooth muscle cells. In this study we examined the effect of hypoxia on ET-1 …

Summary Release of endothelin-1 (ET-1) from the mesenteric arteries of spontaneously
hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were measured by radioimmunoassay …

1 It is generally accepted that endothelial cells secrete endothelin (ET) to the underlying
media which mediates the contractile effects of ET. However, there is some evidence that …

Conversion of porcine big endothelin (big ET) to endothelin (ET) by an extract from cultured
porcine aortic endothelial cells was investigated using a radioimmunoassay (RIA) specific …

Background Endothelin-1 (ET-1) has been shown to exist in many organs and to have
various biologic functions including vasoconstriction. However, an exact location of ET gene …

In comparison with snake venom sarafotoxins S6, the novel, 21-amino acid peptide,
endothelin may have selective coronary artery vasoconstrictor actions. We examined …

In cultured rat aortic smooth muscle cells,[125I] en-dothelin (ET-1) bound to an apparent
single class of high affinity recognition sites with a dissociation constant of 1.84±0.29 nmol/L …

The vascular effects of endothelin-1 (ET) in humans were investigated by brachial artery
infusions of ET into 25 healthy volunteers. Forearm blood flow increased from a mean+/-SD …

Many pathologic conditions are associated with elevations in the production of endothelin-1
(ET-1) in the blood vessel wall. Because many of these conditions are cytokine-driven we …