The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but
as an important modulator and even a driver of tumorigenicity. Within the tumor stromal …

Abstract Cancer-associated fibroblasts (CAFs), as a central component of the tumor
microenvironment in primary and metastatic tumors, profoundly influence the behavior of …

Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

Simple Summary Cancer-associated fibroblasts (CAFs) play an important contributory role in
the microenvironment of tumors. They originate from different cells, have multiple pro-and …

Simple Summary Cancer-associated fibroblasts (CAFs) are found in the tumor
microenvironment and exhibit several protumorigenic functions. Preclinical studies suggest …

Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly
versatile, plastic and resilient cells that are actively involved in cancer progression through …

Simple Summary As our knowledge of cancer as a complex organ comprising tumor cells as
well as surrounding cells within the microenvironment continues to grow, it is imperative to …

Cancer-associated fibroblasts (CAFs) are an integral component of the tumor
microenvironment and have both tumor-promoting and tumor-suppressive functions. This …

Simple Summary Cancer-associated fibroblasts (CAFs) are key players in the tumor
microenvironment. They are responsible for potentiating growth and metastasis through …

Tumors are one of the main causes of death in humans. The development of safe and
effective methods for early diagnosis and treatment of tumors is a difficult problem that needs …