Direct communication between hepatocytes, mediated by gap junctions, constitutes a major
regulatory platform in the control of liver homeostasis, ranging from hepatocellular …

The present review provides the state of the art of the current knowledge concerning gap
junctional channels and their roles in liver functioning. In the first part, we summarize some …

In the normal liver, cells interact closely through gap junctions. By providing a pathway for
the trafficking of low molecular mass molecules, these channels contribute to tissue …

In a recent review article,“Risk Assessment for Possible Carcinogens: A Critical Look”(1), Dr.
Emmanuel Farber states,“There is a developing speculation that agents or circumstances …

Because of their critical role as goalkeepers of hepatic homeostasis, gap junctions are
frequent targets in liver disease. This concept has been demonstrated on many occasions in …

This is a comparative study of the mechanisms by which three different rodent non-genotoxic
carcinogens modulate connexin-mediated gap junction intercellular communication in male …

Gap junctions are a specialized group of cell-to-cell junctions that mediate direct intercellular
communication between cells. They arise from the interaction of two hemichannels of …

Gap junctions (GJs) provide cell-to-cell communication of essential metabolites and ions.
GJs allow tissues to average responses, clear waste products, and minimize the effects of …

The inhibition of gap junctional intercellular communication (GJIC) is a common effect of
nongenotoxic carcinogens and might be a biomarker for these agents. To further test this …

Gap junctional intercellular communication appears to be important in the regulation of
cellular homeostasis, differentiated cell functions, and growth control in adult tissues …