Enteroendocrine cells (EEC) form the basis of the largest endocrine system in the body.
They secrete multiple regulatory molecules which control physiological and homeostatic …

The microbial ecosystem that inhabits the gastrointestinal tract of all mammals—the gut
microbiota—has been in a symbiotic relationship with its hosts over many millennia. Thanks …

The microbial community of the gut conveys significant benefits to host physiology. A clear
relationship has now been established between gut bacteria and host metabolism in which …

The activity of the digestive system is dynamically regulated by external factors, including
body nutritional and activity states, emotions and the contents of the digestive tube. The gut …

The gut epithelium is a barrier between the 'outside'and 'inside'world. The major function of
the epithelium is to absorb nutrients, ions and water, yet it must balance these functions with …

Highlights•EEC dysfunction occurs in a wide array of GI diseases.•EEC dysfunction is
important in GI symptom generation.•EEC dysfunction affects the maintenance of intestinal …

The human microbiome contains a vast array of microbes and genes that show greater
complexity than the host's own karyome; the functions of many of these microbes are …

The gastrointestinal tract plays a role in the development and treatment of metabolic
diseases. During a meal, the gut provides crucial information to the brain regarding …

Obesity is a global epidemic, placing socioeconomic strain on public healthcare systems,
especially within the so-called Western countries, such as Australia, United States, United …

The luminal-mucosal interface of the intestinal tract is the first relevant location where
microorganism-derived antigens and all other potentially immunogenic particles face the …