Exosomes: biogenesis, biologic function and clinical potential

Y Zhang, Y Liu, H Liu, WH Tang - Cell & bioscience, 2019 - Springer
Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of
multivesicular bodies and the plasma membrane. They were shown to carry cell-specific …

Exosomes: potential disease biomarkers and new therapeutic targets

MI Mosquera-Heredia, LC Morales, OM Vidal… - Biomedicines, 2021 - mdpi.com
Exosomes are extracellular vesicles released by cells, both constitutively and after cell
activation, and are present in different types of biological fluid. Exosomes are involved in the …

The exosome journey: from biogenesis to uptake and intracellular signalling

S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …

Current knowledge on exosome biogenesis and release

NP Hessvik, A Llorente - Cellular and Molecular Life Sciences, 2018 - Springer
Exosomes are nanosized membrane vesicles released by fusion of an organelle of the
endocytic pathway, the multivesicular body, with the plasma membrane. This process was …

Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

AV Vlassov, S Magdaleno, R Setterquist… - Biochimica et Biophysica …, 2012 - Elsevier
BACKGROUND: Cells continuously secrete a large number of microvesicles,
macromolecular complexes, and small molecules into the extracellular space. Of the …

Exosomes: new players in cell–cell communication

C Bang, T Thum - The international journal of biochemistry & cell biology, 2012 - Elsevier
Exosomes are small membrane vesicles of endosomal origin, which are secreted from a
variety of cell types. During the 1980s exosomes were first described as organelles to …

Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes

S Gurunathan, MH Kang, M Jeyaraj, M Qasim, JH Kim - Cells, 2019 - mdpi.com
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

Exosome: a new player in translational nanomedicine

H Aheget, M Tristán-Manzano, L Mazini… - Journal of Clinical …, 2020 - mdpi.com
Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo
and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma …

Overview and update on extracellular vesicles: considerations on exosomes and their application in modern medicine

MA Di Bella - Biology, 2022 - mdpi.com
Simple Summary Exosomes are a subpopulation of extracellular vesicles, nanosized
particles, lipid bilayer-enclosed, naturally secreted from cells after the fusion of intracellular …

The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

S Pant, H Hilton, ME Burczynski - Biochemical pharmacology, 2012 - Elsevier
Exosomes are bioactive vesicles derived from the cell's endosomal membrane system and
secreted into surrounding body fluids. Exosomes contain cell and cell-state specific cargos …