Aberrant signal transduction regulating cell growth and proliferation is a hallmark of many
cancers. Activation of mTOR signaling is common and is an attractive therapeutic target with …

Mammalian target of rapamycin (mTOR) pathway is crucial in cell proliferation. Many have
associated its dysregulation with numerous human pathogenic processes. Previously, we …

The mammalian target of rapamycin (mTOR) pathway is crucial in energy metabolism and
cell proliferation. Previously, we reported transcriptome-wide 3′-untranslated region (UTR) …

Targeting mTORC1 is a highly promising strategy in cancer therapy. Suppression of
mTORC1 activity leads to rapid dephosphorylation of eIF4E-binding proteins (4E-BP1–3) …

Rapamycin is a macrolide antibiotic that functions as an immunosuppressive and anti-
cancer agent, and displays robust anti-ageing effects in multiple organisms including …

Post-transcriptional regulations of mRNA transcripts such as alternative splicing and
alternative polyadenylation can affect the expression of genes without changing the …

Translation is a fundamental, energy-consuming, process that permits quick and accurate
responses to cellular and environmental conditions. The mammalian target of rapamycin …

The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Abstract Myeloid cell leukemia 1 (MCL1) is a member of the BCL2-family of proteins
governing the apoptosis pathway and is one of the most frequently amplified genes in …

The mTOR signaling plays an integral role in cellular homeostasis controlling the transition
between the catabolic and anabolic states. Originally approved as immunosuppressive …