The growing focus on brown adipocytes has spurred an interest in their potential benefits for
metabolic diseases. Brown and beige (or brite) adipocytes express high levels of uncoupling …

Uncoupling protein 1 (Ucp1) is the key component of β-adrenergically controlled
nonshivering thermogenesis in brown adipocytes. This process combusts stored and …

Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …

Abstract Uncoupling protein 1 (UCP1) is the hallmark protein responsible for cold-and diet-
induced thermogenesis in brown adipose tissue (BAT). UCP1 activity is protective against …

Summary That uncoupling protein 1 (UCP1) is the sole mediator of adipocyte thermogenesis
is a conventional viewpoint that has primarily been inferred from the attenuation of the …

Apart from UCP1-based nonshivering thermogenesis in brown adipocytes, the identity of
thermogenic mechanisms that can be activated to reduce a positive energy balance is …

Mammals have two types of thermogenic adipocytes: brown adipocytes and beige
adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to …

To examine the thermogenic significance of the classical uncoupling protein-1 (UCP1), the
thermogenic potential of brown adipocytes isolated from UCP1-ablated mice was …

Objective Classical ATP-independent non-shivering thermogenesis enabled by uncoupling
protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in …

Energy expenditure through brown adipose tissue thermogenesis contributes either to
maintenance of body temperature in a cold environment or to wasted food energy, ie cold …