Abstract Melanin formation from 3, 4-dihydroxyphenylalanine (dopa) was studied in the
presence of estradiol and 2-hydroxyestradiol by use of a tyrosinase isolated from B16-F10 …

The activities of mushroom and melanoma tyrosinases towards the estrogens were
compared. While the fungal enzyme is capable of hydroxylating estradiol to the 2-hydroxy …

We have reported previously that 2-hydroxyestradiol can be oxidized in the presence of
catechol by mushroom We have reported previously that 2-hydroxyestradiol can be oxidized …

Previous reports have shown that the tyrosinase activities of melanosomes and soluble
tyrosinase isolated from melanoma were diminished when these preparations were …

ELANIN PIGMENTATION has aroused the curiosity and attention of man since the beginning
of recorded history. This interest stems in part from the social, protective and cosmetic …

To explore the possibility that dopa and 5-S-cysteinyldopa, precursors of melanin, can be
produced in non-melanogenic tissues, this study examined the contents of the free and …

The effect of several polyamines on the activity of tyrosinase from different sources has been
studied. Diaminoethane, 1, 3-diaminopropane and putrescine activated tyrosinase from …

Tyrosinase in a melanosome is known to be inactivated during melanin formation in vivo,
and a similar inactivation was observed in vitro when melanosomes isolated from Harding …

2-Carboxyd, Bdimethoxyindole was synthesized from 6-nitrohomoveratrole by the procedure
of Oxford and Paper (11). The product crystallized from acetone-benzene in tablets which …

Several years later, Raper (17) showed that dopa was the first product formed in the
enzymatic oxidation of tyrosine to melanin by tyrosinase of plant and insect sources. He also …