Colorectal cancer (CRC) is a heterogeneous disorder than arises via multiple distinct
pathways, such as the serrated pathway, in which serrated polyps (including variants of …

In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …

Identification of the serrated neoplasia pathway has improved our understanding of the
pathogenesis of colorectal cancer (CRC). Insights include an increased recognition of the …

Serrated polyps have long been thought to lack malignant potential in the human
colorectum. However, identification of the serrated pathway to colorectal cancer based on …

Approximately 30% of colorectal carcinomas develop via the serrated neoplasia pathway
characterized by widespread DNA methylation and frequent BRAF mutation. Serrated …

The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …

Colorectal cancer (CRC) is considered a heterogeneous disease, both regarding
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …

Serrated lesions of the colorectum are the precursors of perhaps one-third of colorectal
cancers (CRCs). Cancers arising in serrated lesions are usually in the proximal colon, and …

In recent years, the serrated neoplasia pathway where serrated polyps arise as a colorectal
cancer has gained considerable attention as a new carcinogenic pathway. Colorectal …

Context Colorectal cancer is a heterogeneous disease resulting from different molecular
pathways of carcinogenesis. Recent data evaluating the histologic features and molecular …