Local viscoelastic properties of live cells investigated using dynamic and quasi-static atomic force microscopy methods

A Cartagena, A Raman - Biophysical Journal, 2014 - cell.com
The measurement of viscoelasticity of cells in physiological environments with high spatio-
temporal resolution is a key goal in cell mechanobiology. Traditionally only the elastic …

Fast, multi-frequency and quantitative nanomechanical mapping of live cells using the atomic force microscope

AX Cartagena-Rivera, WH Wang, RL Geahlen… - Scientific reports, 2015 - nature.com
A longstanding goal in cellular mechanobiology has been to link dynamic biomolecular
processes underpinning disease or morphogenesis to spatio-temporal changes in …

Mapping heterogeneity of cellular mechanics by multi-harmonic atomic force microscopy

YM Efremov, AX Cartagena-Rivera, AIM Athamneh… - Nature …, 2018 - nature.com
The goal of mechanobiology is to understand the links between changes in the physical
properties of living cells and normal physiology and disease. This requires mechanical …

Measuring biological materials mechanics with atomic force microscopy‐Determination of viscoelastic cell properties from stress relaxation experiments

A Weber, R Benitez… - Microscopy Research and …, 2022 - Wiley Online Library
Cells are complex, viscoelastic bodies. Their mechanical properties are defined by the
arrangement of semiflexible cytoskeletal fibers, their crosslinking, and the active remodeling …

A one-step procedure to probe the viscoelastic properties of cells by Atomic Force Microscopy

YH Chim, LM Mason, N Rath, MF Olson, M Tassieri… - Scientific reports, 2018 - nature.com
The increasingly recognised importance of viscoelastic properties of cells in pathological
conditions requires rapid development of advanced cell microrheology technologies. Here …

Measuring viscoelasticity of soft biological samples using atomic force microscopy

YM Efremov, T Okajima, A Raman - Soft matter, 2020 - pubs.rsc.org
Mechanical properties play important roles at different scales in biology. At the level of a
single cell, the mechanical properties mediate mechanosensing and mechanotransduction …

Noncontact viscoelastic imaging of living cells using a long-needle atomic force microscope with dual-frequency modulation

D Guan, E Charlaix, RZ Qi, P Tong - Physical Review Applied, 2017 - APS
Imaging of surface topography and elasticity of living cells can provide insight into the roles
played by the cells' volumetric and mechanical properties and their response to external …

Mapping nanomechanical properties of live cells using multi-harmonic atomic force microscopy

A Raman, S Trigueros, A Cartagena… - Nature …, 2011 - nature.com
The nanomechanical properties of living cells, such as their surface elastic response and
adhesion, have important roles in cellular processes such as morphogenesis, mechano …

Single‐cell elastography: probing for disease with the atomic force microscope

KD Costa - Disease markers, 2004 - Wiley Online Library
The atomic force microscope (AFM) is emerging as a powerful tool in cell biology. Originally
developed for high‐resolution imaging purposes, the AFM also has unique capabilities as a …

Combined atomic force microscopy (AFM) and traction force microscopy (TFM) reveals a correlation between viscoelastic material properties and contractile prestress …

N Schierbaum, J Rheinlaender, TE Schäffer - Soft Matter, 2019 - pubs.rsc.org
Living cells exhibit a complex mechanical behavior, whose underlying mechanisms are still
largely unknown. Emerging from the molecular structure and dynamics of the cytoskeleton …