Nucleotides regulate various effects including vascular tone. This study was aimed to
characterize P2Y receptors on endothelial cells of the aorta of C57BL6 mice. Five adjacent …

Based on pharmacological criteria, we previously suggested that in the mouse aorta,
endothelium‐dependent relaxation by nucleotides is mediated by P2Y1 (adenosine …

Previous studies have shown that ATP and UTP are able to stimulate phospholipase C
(PLC) and proliferation in cultured aortic smooth muscle cells. Here we set out to …

P2 receptors mediate the actions of the extracellular nucleotides ATP, ADP, UTP, and UDP,
regulating several physiologic responses including cardiac function, vascular tone, smooth …

It has previously been shown that ATP and UTP stimulate P2Y receptors in vascular smooth
muscle cells (VSMCs), but the nature of these receptors, in particular the contribution of …

Background and purpose: The uracil nucleotides UDP and UTP have been reported to
activate P2Y2, P2Y4 and P2Y6 receptors to cause vasoconstriction. We have performed a …

The contractile and relaxant effects of the different P2 receptors were characterized in the rat
isolated mesenteric artery by use of extracellular nucleotides, including the stable …

The receptors through which 2-methylthio ATP (MeSATP), adenosine 5′-O-(2-
thiodiphosphate)(ADPβS), UTP and ATP elicit endothelium-dependent relaxation of …

It has recently been demonstrated that two types of ATP receptors, the P2y and P2u
receptors, are coexpressed on bovine aortic endothelial cells. The aim of the present study …

Background and Purpose There is a lack of potent, selective antagonists at most subtypes of
P2Y receptor. The aims of this study were to characterise the pharmacological properties of …