Bacteria possess a repertoire of tools which function to aid in the competition for nutrients
and space in their environment. One strategy employed in this competitive behavior involves …

After antibiotic treatment, a subpopulation of bacteria often remains and can lead to
recalcitrant infections. This subpopulation, referred to as persisters, evades antibiotic …

The emergence of bacterial resistance is a major threat to global health. Alongside this
issue, formation of bacterial biofilms is another cause of concern because most antibiotics …

Despite our continued efforts to assert control over pathogens, more and more bacteria are
saying “no” to drugs. It is becoming increasingly apparent that microbial environments …

Leaky barrier boosts antibiotic action | Nature Reviews Microbiology Skip to main content
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With the emerging threat of infections caused by multidrug resistant bacteria, phages have
been reconsidered as an alternative for treating infections caused by tenacious pathogens …

Current strategies for treating bacterial infections are dwindling as bacteria continue to
evolve resistance and evade treatments. Our current arsenal of antibiotics mainly consists of …

Increasing resistance and decreasing numbers of antibiotics reaching the market point to a
growing need for novel antibacterial drugs. Most antibiotics are very inefficient at killing non …

Antibiotic drug–target interactions, and their respective direct effects, are generally well
characterized. By contrast, the bacterial responses to antibiotic drug treatments that …

The vast majority of bactericidal antibiotics display poor efficacy against bacterial persisters,
cells that are in a metabolically repressed state. Molecules that retain their bactericidal …