Brain ischaemia is a frequent and important sequel to brain injury. Areas of ischaemic brain
damage are an almost invariable finding at postmortem in patients who have sustained …

Irreversible hypoxic brain damage may occur as a consequence of such diverse conditions
as lung and heart disease, shock, seizures or an episode of severe hypotension, and is a …

MEASURING THE BURDEN OF SECONDARY INSULTS IN HEAD INJURED PATIENTS
DURING INTENSIVE CARE Patricia A. Jones, Peter JD Andrews, ^Susan Midgley, Shirley I …

The knowledge of the pathophysiology after traumatic head injury is necessary for adequate
and patient-oriented treatment. As the primary insult, which represents the direct mechanical …

Background: In patients with severe head injury, control of physiological variables is
important to avoid intracranial hypertension and secondary injury to the brain. The aims of …

The incidence and distribution of ischaemic brain damage in a consecutive series of 151
patients who died as a result of a non-missile head injury in the Institute of Neurological …

At the present time, brain oedema is classified into two types: cytotoxicand vasogenic
(Klatzo, 1967) in accordance with two basically different pathological mechanisms involved …

After many years of research, drug treatment in cerebral hypoxia is still controversial and no
treatment appears to be firmly established. Not even the mechanisms causing damage have …

This review examines the evidence base for the early management of head‐injured patients.
Traumatic brain injury (TBI) is common, carries a high morbidity and mortality, and has no …

As triage and resuscitation protocols evolve, it is critical to determine the major extracranial
variables influencing outcome in the setting of severe head injury. We prospectively studied …