About 30 years ago the proceedings of the Cold Spring Harbor Symposium in Quantitative
Biology entitled 'The Mechanism of Muscle Contraction'was published. A key topic in that …

The discovery of “native tropomyosin”(Ebashi, 1963), which confers Ca sensitivity on the
myosin—actin-ATP interaction, and its separation into classical tropomyosin and a new …

In striated muscle, regulation of actin-myosin interactions depends on a series of
conformational changes within the thin filament that result in a shifting of the tropomyosin …

The control of vertebrate striated muscle from rest to activity is regulated by the combination
of the regulatory proteins tropomyosin and troponin on the thin actin filament (see reviews by …

Contraction in all muscles must be precisely regulated and requisite control systems must be
able to adjust to changes in physiological and myopathic stimuli. In this chapter, we outline …

This review deals with the regulatory system of striated muscle. In current parlance, the term
regulatory system refers to those proteins that are located in the so-called thin filaments of …

In striated muscle, regulation of actin-myosin interactions depends on a series of
conformational changes within the thin filament that result in a shifting of the tropomyosin …

Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

Cellular movement and function have long been known to depend on the actin cytoskeleton
and its regulation. The actin cytoskeleton is the ultimate target of numerous cellular signaling …

Molecular control mechanisms in muscle contraction. Page 1 PHYSIOLOGICAL REVIE ws
Vol. 53, No. 3, July 1973 Printed in USA Molecular Control Mechanisms in Muscle …