Protective effect of carnosic acid against paraquat-induced redox impairment and mitochondrial dysfunction in SH-SY5Y cells: Role for PI3K/Akt/Nrf2 pathway

MR de Oliveira, GC Ferreira, PF Schuck - Toxicology in Vitro, 2016 - Elsevier
Carnosic acid (CA) is a phenolic diterpene isolated from Rosmarinus officinalis and exerts
anti-inflammatory, antioxidant, and anticarcinogenic activities in different cell types. It has …

Carnosic acid affords mitochondrial protection in chlorpyrifos-treated Sh-Sy5y cells

MR de Oliveira, A Peres, GC Ferreira, PF Schuck… - Neurotoxicity …, 2016 - Springer
Abstract Carnosic acid (CA; C 20 H 28 O 4) is a phenolic diterpene found in rosemary
(Rosmarinus officinalis L.) and exhibits protective properties, eg, antioxidant, anti …

Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson's disease: involvement of antioxidative enzymes …

CR Wu, CW Tsai, SW Chang, CY Lin… - Chemico-Biological …, 2015 - Elsevier
The neuroprotective effects of carnosic acid (CA), a phenolic diterpene isolated from
rosemary (Rosmarinus officinalis), have been widely investigated in recent years, however …

Carvacrol protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro models of Parkinson's disease

M Manouchehrabadi, M Farhadi, Z Azizi… - Neurotoxicity …, 2020 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder
characterized by selective loss of dopaminergic neurons that project from the substantia …

Neuroprotective effects of Cassia tora against paraquat-induced neurodegeneration: relevance for Parkinson's disease

SK Ravi, RB Narasingappa, CG Joshi… - Natural product …, 2018 - Taylor & Francis
The aim of the present study was to determine whether Cassia tora extracts could reverse
the oxidative stress-induced neurodegeneration in a Parkinson's disease in vitro model. The …

Promotion of mitochondrial biogenesis via the regulation of PARIS and PGC-1α by parkin as a mechanism of neuroprotection by carnosic acid

CY Lin, YN Huang, RH Fu, YH Liao, TY Kuo, CW Tsai - Phytomedicine, 2021 - Elsevier
Background Impairment of mitochondrial biogenesis is associated with the pathological
progression of Parkinson's disease (PD). Parkin-interacting substrate (PARIS) can be …

N‐acetylcysteine alleviated paraquat‐induced mitochondrial fragmentation and autophagy in primary murine neural progenitor cells

G Xiong, L Zhao, M Yan, X Wang… - Journal of Applied …, 2019 - Wiley Online Library
The developing brain is uniquely vulnerable to toxic chemical exposures. Studies indicate
that neural stem cell (NSC) self‐renewal is susceptible to oxidative stress caused by …

Carnosic acid protects mitochondria of human neuroblastoma SH-SY5Y cells exposed to paraquat through activation of the Nrf2/HO-1Axis

MR de Oliveira, A Peres, GC Ferreira, PF Schuck… - Molecular …, 2017 - Springer
Abstract Carnosic acid (CA; C 20 H 28 O 4), which is also called salvin, is a major phenolic
diterpene found in Rosmarinus officinalis L. and exhibits antioxidant, anti-inflammatory, and …

Carnosic acid induces anti-inflammatory effects in paraquat-treated SH-SY5Y cells through a mechanism involving a crosstalk between the Nrf2/HO-1 axis and NF-κB

MR de Oliveira, ICC de Souza, CR Fürstenau - Molecular neurobiology, 2018 - Springer
Carnosic acid (CA) is a phenolic diterpene obtained from Rosmarinus officinalis L. and has
demonstrated cytoprotective properties in several experimental models. CA exerts …

[HTML][HTML] Carvacrol prevents impairments in motor and neurochemical parameters in a model of progressive parkinsonism induced by reserpine

LCRF Lins, MF Souza, JMM Bispo, AM Gois… - Brain Research …, 2018 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
degeneration of dopaminergic neurons in the substantia nigra pars compact (SNpc), with …