Perfluorocarbon-based oxygen carriers: from physics to physiology

J Jägers, A Wrobeln, KB Ferenz - Pflügers Archiv-European Journal of …, 2021 - Springer
Developing biocompatible, synthetic oxygen carriers is a consistently challenging task that
researchers have been pursuing for decades. Perfluorocarbons (PFC) are fascinating …

Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics

BD Spiess - Journal of Applied Physiology, 2009 - journals.physiology.org
Perfluorocarbon (PFC) emulsions are halogen-substituted carbon nonpolar oils with
resultant enhanced dissolved respiratory gas (O2, N2, CO2, nitric oxide) capabilities. In the …

Understanding the Fundamentals of Perfluorocarbons and Perfluorocarbon Emulsions Relevant to In Vivo Oxygen Delivery

JG Riess - Artificial cells, blood substitutes, and biotechnology, 2005 - Taylor & Francis
The unique behavior of perfluorocarbons (PFCs), including their high oxygen dissolving
capacity, hydrophobic and lipophobic character, and extreme inertness, derive directly, in a …

Therapeutic oxygen delivery by perfluorocarbon-based colloids

MP Krafft, JG Riess - Advances in colloid and interface science, 2021 - Elsevier
After the protocol-related indecisive clinical trial of Oxygent, a perfluorooctylbromide/
phospholipid nanoemulsion, in cardiac surgery, that often unduly assigned the observed …

Alleviating tumor hypoxia with perfluorocarbon-based oxygen carriers

MP Krafft - Current Opinion in Pharmacology, 2020 - Elsevier
Highlights•PFCs efficiently deliver O 2 to tumor tissues, and can alleviate hypoxia.•PFC-
based O 2 nanocarriers increase 1 O 2 lifetime, enhancing PDT/SDT, radiotherapy and …

Pharmacokinetics and side effects of perfluorocarbon-based blood substitutes

SF Flaim - Artificial Cells, Blood Substitutes, and Biotechnology, 1994 - Taylor & Francis
Perfluorochemicals are fluorine-saturated carbon-based molecules which demonstrate utility
in the areas of imaging and oxygen delivery. In general, these molecules are biologically …

Fluorocarbons and fluorinated amphiphiles in drug delivery and biomedical research

MP Krafft - Advanced drug delivery reviews, 2001 - Elsevier
The specific properties of fluorocarbons, exceptional chemical and biological inertness, high
gas-dissolving capacity, low surface tension, excellent spreading characteristics and high …

Perfluorocarbons: Life sciences and biomedical uses Dedicated to the memory of Professor Guy Ourisson, a true RENAISSANCE man.

MP Krafft, JG Riess - Journal of Polymer Science Part A …, 2007 - Wiley Online Library
Perfluorocarbons are primarily characterized by outstanding chemical and biological
inertness, and intense hydrophobic and lipophobic effects. The latter effects provide a …

Overview of Progress in the Fluorocarbon Approach to in vivo Oxygen Delivery

JG Riess - Biomaterials, Artificial Cells and Immobilization …, 1992 - Taylor & Francis
The development of fluorocarbon-based oxygen carriers has experienced rapid progress
over the past few years. Fluosol® has been approved for use during percutaneous …

Emerging nanomedicine opportunities with perfluorocarbon nanoparticles

PM Winter, K Cai, SD Caruthers… - Expert Review of …, 2007 - Taylor & Francis
Perfluorocarbon (PFC) nanoparticles can serve as a platform technology for molecular
imaging and targeted drug-delivery applications. These nanoparticles are approximately …