Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis

W Zhao, DR Beers, SH Appel - Journal of Neuroimmune Pharmacology, 2013 - Springer
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with
selective loss of upper and lower motor neurons. At sites of motor neuron injury …

Non‐neuronal cells in ALS: Role of glial, immune cells and blood‐CNS barriers

F Puentes, A Malaspina, JM Van Noort… - Brain …, 2016 - Wiley Online Library
Neurological dysfunction and motor neuron degeneration in amyotrophic lateral sclerosis
(ALS) is strongly associated with neuroinflammation reflected by activated microglia and …

[HTML][HTML] Protective and toxic neuroinflammation in amyotrophic lateral sclerosis

KG Hooten, DR Beers, W Zhao, SH Appel - Neurotherapeutics, 2015 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous disorder characterized by
loss of motor neurons, resulting in paralysis and death. Multiple mechanisms of motor …

[HTML][HTML] Innate immunity in amyotrophic lateral sclerosis

K Moisse, MJ Strong - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2006 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition in which motor
neurons are selectively targeted. Although the underlying cause remains unclear, evidence …

Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective

A Malaspina, F Puentes, S Amor - International immunology, 2015 - academic.oup.com
The immune system is inextricably linked with many neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS), a devastating neuromuscular disorder affecting motor …

[HTML][HTML] Role of neuroinflammation in amyotrophic lateral sclerosis: cellular mechanisms and therapeutic implications

J Liu, F Wang - Frontiers in immunology, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …

Immunity in amyotrophic lateral sclerosis: Blurred lines between excessive inflammation and inefficient immune responses

LC Béland, A Markovinovic, H Jakovac… - Brain …, 2020 - academic.oup.com
Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral
sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons …

Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact

F De Marchi, I Munitic, A Amedei, JD Berry… - Neuroscience & …, 2021 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative
disease. Despite decades of research and many new insights into disease biology over the …

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

DR Beers, SH Appel - The Lancet Neurology, 2019 - thelancet.com
Neuroinflammation is a common pathological feature of many neurodegenerative diseases,
including amyotrophic lateral sclerosis (ALS), and is characterised by activated CNS …

The dual roles of immunity in ALS: injury overrides protection

BJ Murdock, DE Bender, BM Segal, EL Feldman - Neurobiology of disease, 2015 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease
affecting motor neurons. Disease progression is accompanied by a multi-phased immune …