Optimisation and validation of a HS-SPME–GC–IT/MS method for analysis of carbonyl volatile compounds as biomarkers in human urine: Application in a pilot study to …

I Calejo, N Moreira, AM Araújo, M Carvalho… - Talanta, 2016 - Elsevier
A new and simple analytical approach consisting of an automated headspace solid-phase
microextraction (HS-SPME) sampler coupled to gas chromatography-ion trap/mass …

Freeze-drying: an alternative method for the analysis of volatile organic compounds in the headspace of urine samples using solid phase micro-extraction coupled to …

RBM Aggio, A Mayor, S Coyle, S Reade… - Chemistry Central …, 2016 - Springer
Abstract Background Volatile organic compounds (VOCs) can be intermediates of metabolic
pathways and their levels in biological samples may provide a better understanding about …

Headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry for the determination of volatile organic compounds in urine

N Drabińska, M Starowicz, U Krupa-Kozak - Journal of Analytical …, 2020 - Springer
Determination of volatile organic compounds (VOCs), the metabolites produced in human
body, contributes to better understanding of the mechanisms responsible for the progression …

HS-SPME determination of volatile carbonyl and carboxylic compounds in different matrices

EE Stashenko, AL Mora, M Cervantes… - Journal of …, 2006 - academic.oup.com
Specific chromatographic methodologies are developed for the analysis of carboxylic acids
(C2-C6, benzoic) and aldehydes (C2-C10) of low molecular weight in diverse matrices, such …

Gas chromatographic-mass spectrometric analysis of urinary volatile organic metabolites: Optimization of the HS-SPME procedure and sample storage conditions

TŽ Semren, IB Karačonji, T Safner, N Brajenović… - Talanta, 2018 - Elsevier
Non-targeted metabolomics research of human volatile urinary metabolome can be used to
identify potential biomarkers associated with the changes in metabolism related to various …

Investigation of urinary volatile organic metabolites as potential cancer biomarkers by solid-phase microextraction in combination with gas chromatography-mass …

CL Silva, M Passos, JS Câmara - British journal of cancer, 2011 - nature.com
Background: Non-invasive diagnostic strategies aimed at identifying biomarkers of cancer
are of great interest for early cancer detection. Urine is potentially a rich source of volatile …

Exploring the human urine metabolomic potentialities by comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry

SM Rocha, M Caldeira, J Carrola, M Santos… - … of Chromatography A, 2012 - Elsevier
Metabolomics represents an emerging issue that can aid in the diagnosis and/or prognosis
of different diseases. Metabolomic study of urine is particularly interesting as it can be on the …

Headspace SPME-GC-MS metabolomics analysis of urinary volatile organic compounds (VOCs)

S Zhang, D Raftery - Mass Spectrometry in Metabolomics: Methods and …, 2014 - Springer
In this chapter, we describe the procedure for metabolic profiling of hundreds of urinary
volatile organic compounds (VOCs) using headspace solid-phase microextraction (SPME) …

Analysis of exhaled breath from cigarette smokers using CMV-GC/MS

J Almirall - Forensic Chemistry, 2017 - Elsevier
The aim of this research was to investigate the potential of a novel preconcentration device,
capillary micro-extraction of volatiles (CMV), for the application of breath analysis. The CMV …

Optimisation of urine sample preparation for headspace-solid phase microextraction gas chromatography-mass spectrometry: altering sample pH, sulphuric acid …

P Aggarwal, J Baker, MT Boyd, S Coyle, C Probert… - Metabolites, 2020 - mdpi.com
Headspace-solid phase microextraction gas chromatography-mass spectrometry (HS-SPME-
GC-MS) can be used to measure volatile organic compounds (VOCs) in human urine …