FleQ DNA binding consensus sequence revealed by studies of FleQ-dependent regulation of biofilm gene expression in Pseudomonas aeruginosa

C Baraquet, CS Harwood - Journal of bacteriology, 2016 - Am Soc Microbiol
The transcription factor FleQ from Pseudomonas aeruginosa derepresses expression of
genes involved in biofilm formation when intracellular levels of the second messenger cyclic …

The FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response …

C Baraquet, K Murakami, MR Parsek… - Nucleic acids …, 2012 - academic.oup.com
Abstract Bis-(3′–5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) modulates the
transition between planktonic and biofilm life styles. In response to c-di-GMP, the enhancer …

[HTML][HTML] FleQ of Pseudomonas putida KT2440 is a multimeric cyclic diguanylate binding protein that differentially regulates expression of biofilm matrix components

MA Molina-Henares, MI Ramos-González… - Research in …, 2017 - Elsevier
The intracellular signal molecule cyclic di-GMP (c-di-GMP) is an important element in
regulation of biofilm formation by bacteria. In Pseudomonas aeruginosa, FleQ functions as a …

Mechanistic insights into c-di-GMP–dependent control of the biofilm regulator FleQ from Pseudomonas aeruginosa

BY Matsuyama, PV Krasteva… - Proceedings of the …, 2016 - National Acad Sciences
Bacterial biofilm formation during chronic infections confers increased fitness, antibiotic
tolerance, and cytotoxicity. In many pathogens, the transition from a planktonic lifestyle to …

Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ

C Baraquet, CS Harwood - Proceedings of the National …, 2013 - National Acad Sciences
The transcription factor FleQ is a bacterial AAA+ ATPase enhancer-binding protein that is
the master activator of flagella gene expression in the opportunistic bacterial pathogen …

Complex interplay between FleQ, cyclic diguanylate and multiple σ factors coordinately regulates flagellar motility and biofilm development in Pseudomonas putida

A Jiménez-Fernández, A López-Sánchez… - PLoS …, 2016 - journals.plos.org
Most bacteria alternate between a free living planktonic lifestyle and the formation of
structured surface-associated communities named biofilms. The transition between these …

Genetic Analysis of the AdnA Regulon in Pseudomonas fluorescens: Nonessential Role of Flagella in Adhesion to Sand and Biofilm Formation

EA Robleto, I López-Hernández, MW Silby… - Journal of …, 2003 - Am Soc Microbiol
AdnA is a transcription factor in Pseudomonas fluorescens that affects flagellar synthesis,
biofilm formation, and sand adhesion. To identify the AdnA regulon, we used a promoterless …

Fis overexpression enhances Pseudomonas putida biofilm formation by regulating the ratio of LapA and LapF

H Moor, A Teppo, A Lahesaare, M Kivisaar… - …, 2014 - microbiologyresearch.org
Bacteria form biofilm as a response to a number of environmental signals that are mediated
by global transcription regulators and alarmones. Here we report the involvement of the …

A transcriptional activator, FleQ, regulates mucin adhesion and flagellar gene expression in Pseudomonas aeruginosa in a cascade manner

SK Arora, BW Ritchings, EC Almira, S Lory… - Journal of …, 1997 - Am Soc Microbiol
Previous work has demonstrated that fleR, the gene for a transcriptional activator belonging
to the NtrC subfamily of response regulators, is involved in the regulation of mucin adhesion …

The REC domain mediated dimerization is critical for FleQ from Pseudomonas aeruginosa to function as a c-di-GMP receptor and flagella gene regulator

T Su, S Liu, K Wang, K Chi, D Zhu, T Wei… - Journal of structural …, 2015 - Elsevier
FleQ is an AAA+ ATPase enhancer-binding protein that regulates both flagella and biofilm
formation in the opportunistic pathogen Pseudomonas aeruginosa. FleQ belongs to the NtrC …