miR-29a levels are elevated in the db/db mice liver and its overexpression leads to attenuation of insulin action on PEPCK gene expression in HepG2 cells
MicroRNAs comprise a class of small (∼ 22 nucleotide) non-coding RNA species and they
bind to their complementary sequence on the 3′ UTR of target genes and cause …
bind to their complementary sequence on the 3′ UTR of target genes and cause …
Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes
A He, L Zhu, N Gupta, Y Chang… - Molecular endocrinology, 2007 - academic.oup.com
Micro-RNAs (miRNAs) have been suggested to play pivotal roles in multifarious diseases
associated with the posttranscriptional regulation of protein-coding genes. In this study, we …
associated with the posttranscriptional regulation of protein-coding genes. In this study, we …
Regulation of microRNA-375 by cAMP in Pancreatic β-Cells
DM Keller, EA Clark, RH Goodman - Molecular endocrinology, 2012 - academic.oup.com
Abstract MicroRNA-375 (miR-375) is necessary for proper formation of pancreatic islets in
vertebrates and is necessary for the development of β-cells in mice, but regulation of miR …
vertebrates and is necessary for the development of β-cells in mice, but regulation of miR …
miR-375 targets 3′-phosphoinositide–dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic β-cells
A El Ouaamari, N Baroukh, GA Martens, P Lebrun… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—MicroRNAs are short, noncoding RNAs that regulate gene expression. We
hypothesized that the phosphatidylinositol 3-kinase (PI 3-kinase) cascade known to be …
hypothesized that the phosphatidylinositol 3-kinase (PI 3-kinase) cascade known to be …
microRNA-375 regulates glucose metabolism-related signaling for insulin secretion
O Dumortier, G Fabris, DF Pisani… - Journal of …, 2020 - joe.bioscientifica.com
Enhanced beta cell glycolytic and oxidative metabolism are necessary for glucose-induced
insulin secretion. While several microRNAs modulate beta cell homeostasis, miR-375 …
insulin secretion. While several microRNAs modulate beta cell homeostasis, miR-375 …
MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells
MicroRNAs (miRNAs) represent small noncoding RNAs that play a role in many diseases,
including diabetes. miRNAs target genes important for pancreas development, β-cell …
including diabetes. miRNAs target genes important for pancreas development, β-cell …
The microRNA-29 family dictates the balance between homeostatic and pathological glucose handling in diabetes and obesity
J Dooley, JE Garcia-Perez, J Sreenivasan… - Diabetes, 2016 - Am Diabetes Assoc
The microRNA-29 (miR-29) family is among the most abundantly expressed microRNA in
the pancreas and liver. Here, we investigated the function of miR-29 in glucose regulation …
the pancreas and liver. Here, we investigated the function of miR-29 in glucose regulation …
A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis
F Xiao, J Yu, B Liu, Y Guo, K Li, J Deng, J Zhang… - Diabetes, 2014 - Am Diabetes Assoc
MicroRNAs (miRNAs) are endogenous, noncoding, short, single-stranded RNAs that are
evolutionarily conserved and believed to play a role in controlling a variety of biological …
evolutionarily conserved and believed to play a role in controlling a variety of biological …
Identification of glucose-regulated miRNAs from pancreatic β cells reveals a role for miR-30d in insulin transcription
MicroRNAs (miRNAs) are small noncoding ribonucleotides that bind mRNAs and function
mainly as translational repressors in mammals. MicroRNAs have been implicated to play a …
mainly as translational repressors in mammals. MicroRNAs have been implicated to play a …
Coexpression of an intronic microRNA and its host gene reveals a potential role for miR-483-5p as an IGF2 partner
N Ma, X Wang, Y Qiao, F Li, Y Hui, C Zou, J Jin… - Molecular and cellular …, 2011 - Elsevier
MicroRNAs (miRNAs) are endogenous noncoding RNAs that downregulate gene
expression by inhibiting translation or promoting mRNA degradation. Although over one …
expression by inhibiting translation or promoting mRNA degradation. Although over one …