So far brain metastases represent a critical stage of a disease course and the frequency is
increasing over the years. The treatment of brain metastases should be individualized for …

Background. Brain metastases are a very common neurological sequela in cancer patients.
The ability of current anticancer therapies to prolong overall survival is beleaguered by this …

Brain metastases occur in almost one-third of adult patients with solid tumor malignancies
and lead to considerable patient morbidity and mortality. The rising incidence of brain …

The development of brain metastases occurs in 10–20% of all patients with cancer. Brain
metastases portend poor survival and contribute to increased cancer mortality and morbidity …

Background Brain metastases are the commonest neurological manifestation of cancer and
a major cause of morbidity in cancer patients. Brain metastases are increasing in frequency …

Brain metastases Page 443 CHAPTER 30 Brain m etastases R. Soffietti, 1 P. Cornu, 2 JY
Delattre, 3 R. Grant, 4 F. Graus, 5 W. Grisold, 6 J. Heimans, 7 J. Hildebrand, 8 P. Hoskin, 9 M …

Brain metastases are significant causes of morbidity or mortality for patients with metastatic
cancer. With the application of novel systematic therapy and improvement of overall survival …

Background 20–40% of patients with malignant tumors have one or more brain metastases
in the course of their illness. Brain metastases are the first manifestation of cancer in 5–10 …

Brain metastases are a common complication of cancer and continue to be associated with
a poor prognosis. Management of brain metastases typically requires a multidisciplinary …

The challenge of the management of brain metastases has not finished yet. Although new
diagnosis-specific prognostic assessment classifications and guidelines for patients with …