Calcimimetics are positive allosteric modulators to the calcium-sensing receptor (CaSR).
Activation of the CaSR inhibits the secretion of parathyroid hormone (PTH), stimulates the …

The actions of extracellular Ca 2+ in regulating parathyroid gland and kidney functions are
mediated by the extracellular calcium receptor (CaR), a G protein-coupled receptor. The …

A hallmark of chronic kidney disease is hyperphosphatemia due to renal phosphate
retention. Prolonged parathyroid gland exposure to hyperphosphatemia leads to secondary …

Calcimimetics, which activate the extracellular calcium (Cao2+)-sensing receptor in the
parathyroid and other tissues participating in Cao2+ homeostasis, were the first described …

The calcium sensing receptor (CaR) is a G protein-coupled receptor (GPCR) that plays a
fundamental role in serum calcium homeostasis. The CaR is expressed on the chief cells of …

The extracellular calcium receptor (CaR) is a Family CG protein-coupled receptor that
controls systemic Ca2+ homeostasis, largely by regulating the secretion of parathyroid …

Parathyroid hormone (PTH) secreted from parathyroid cells is a key regulator of circulating
levels of calcium ion, which is maintained within a narrow physiological range mainly by the …

Cinacalcet HCl, an allosteric modulator of the calcium-sensing receptor (CaR), has recently
been approved for the treatment of secondary hyperparathyroidism in patients with chronic …

Background and Purpose Clinical use of cinacalcet in hyperparathyroidism is complicated
by its tendency to induce hypocalcaemia, arising partly from activation of calcium‐sensing …

The extracellular calcium receptor (CaR) is a G protein-coupled receptor (GPCR) and the
pivotal molecule regulating systemic Ca 2+ homeostasis. The CaR was a challenging target …