Drug delivery to the central nervous system (CNS) remains a challenge in neuro-oncology.
Despite decades of research in this field, no consensus has emerged as to the best …

Drug delivery to the central nervous system (CNS) remains a challenge in neuro-oncology.
Despite decades of research in this field, no consensus has emerged as to the best …

The blood-brain barrier (BBB) is a gate that controls the influx and efflux of a wide variety of
substances and consequently restricts the delivery of drugs into the central nervous system …

BACKGROUND The treatment of malignant brain tumors is hampered by the presence of the
blood‐brain barrier, which limits chemotherapy penetration to the central nervous system …

Introduction Intra-arterial (IA) delivery of therapeutic agents across the blood-brain barrier
(BBB) is an evolving strategy which enables the distribution of high concentration …

The blood-brain barrier (BBB) to water-soluble drugs and macromolecules can be opened in
vivo by infusing a hypertonic solution of arabinose or mannitol into the carotid artery for 30 …

Glioblastoma (GBM) is the most common primary brain tumor and carries a grave prognosis.
Despite years of research investigating potentially new therapies for GBM, the median …

Background: Malignant brain tumors are among the most challenging to treat and at present
there are no uniformly successful treatment strategies. Standard treatment regimens consist …

The effective treatment of brain tumors is a considerable challenge in part due to the
presence of the blood-brain barrier (BBB) that limits drug delivery. Multiple hurdles pose …

A prerequisite for the efficacy of any cancer drug is that it reaches the tumor in therapeutic
concentrations. This is difficult to accomplish in most systemic solid tumors because of …