Due to recent advances in experimental and theoretical approaches, the dynamic three-
dimensional organization (3D) of the nucleus has become a very active area of research in …

Genomic architecture appears to play crucial roles in health and a variety of diseases. How
nuclear structures reorganize over different timescales is elusive, partly because the tools …

The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …

Abstract The 4D Nucleome Network aims to develop and apply approaches to map the
structure and dynamics of the human and mouse genomes in space and time with the goal …

The intrinsic dynamic nature of chromosomes is emerging as a fundamental component in
regulating DNA transcription, replication, and damage-repair among other nuclear functions …

Recent experimental observations suggest a strong coupling between the 3D nuclear
chromosome organization and epigenomics. However, the mechanistic and functional …

Genome-wide sequencing technologies enable investigations of the structural properties of
the genome in various spatial dimensions. Here, we review computational techniques …

Eukaryotic genomes are organized into chromatin domains. The molecular mechanisms
driving the formation of these domains are difficult to dissect in vivo and remain poorly …

A decade of rapid method development has begun to yield exciting insights into the 3D
architecture of the metazoan genome and the roles it may play in regulating transcription …

Dominated by microscopy for decades the nuclear genome organization field has recently
undergone a dramatic transition fuelled by new next generation sequencing technologies …