While adipose tissue-associated macrophages contribute to development of chronic
inflammation and insulin resistance of obesity, little is known about the role of hepatic …

Recruited adipose tissue macrophages contribute to chronic and low-grade inflammation
causing insulin resistance in obesity. Similarly, we hypothesized here that Kupffer cells, the …

Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin
resistance and type 2 diabetes. While inflammatory activation of resident hepatic …

Kupffer cells have been implicated in the pathogenesis of various liver diseases. However,
their involvement in metabolic disorders of the liver, including fatty liver disease, remains …

OBJECTIVE Increased activity of the innate immune system has been implicated in the
pathogenesis of the dyslipidemia and insulin resistance associated with obesity and type 2 …

High-fat diet-induced obesity (DIO) is associated with fatty liver and elevated IL-6 circulating
levels. IL-6 administration in rodents has yielded contradictory results regarding its effects on …

The contribution of interleukin (IL)-6 signaling in obesity-induced inflammation remains
controversial. To specifically define the role of hepatic IL-6 signaling in insulin action and …

Interleukin-10 (IL-10) is an endogenous factor that restrains hepatic insulin resistance in diet-
induced steatosis. Reducing IL-10 expression increases proinflammatory activity in the …

Non-alcoholic fatty liver disease is prevalent in human obesity and type 2 diabetes, and is
characterized by increases in both hepatic triglyceride accumulation (denoted as steatosis) …

The objective of this study was to reveal the exact role of Kupffer cells in the diet-induced
insulin resistance, inflammation and liver autophagy. C57BL/6j male mice were fed with …