OBJECTIVE In glioblastoma (GBM) patients, controlling the microenvironment around the
tumor using various treatment modalities, including surgical intervention, is essential in …

OBJECTIVE In glioblastoma (GBM) patients, controlling the microenvironment around the
tumor using various treatment modalities, including surgical intervention, is essential in …

Background Malignant gliomas are the most prevalent primary malignant cerebral tumors.
Preoperative imaging plays an important role, and the prognosis is closely related to …

Background: Glioblastoma (GBM) is the most common primary brain tumor. The extent of
resection (EOR) has been claimed as one of the most important prognostic factors …

Background The intratumoral heterogeneity of high-grade gliomas (HGGs) is associated
with isocitrate dehydrogenase (IDH) status and prognosis, which can be established by …

OBJECTIVE The authors' goal was to use a multicenter, observational cohort study to
determine whether supramarginal resection (SMR) of FLAIR-hyperintense tumor beyond the …

OBJECTIVE Recent studies have proposed resection of the T2 FLAIR hyperintensity beyond
the T1 contrast enhancement (supramarginal resection [SMR]) for IDH–wild-type …

Importance Per the World Health Organization 2016 integrative classification, newly
diagnosed glioblastomas are separated into isocitrate dehydrogenase gene 1 or 2 (IDH) …

It is commonly reported that maximizing surgical resection of contrast-enhancing regions in
patients with glioblastoma improves overall survival. Efforts to achieve an improved rate of …

IDH mutation, a key factor in predicting glioma prognosis, alters the levels of some
metabolites in brain, including 2-hydroxyglutarate (2HG), glutamine (Gln), and glutathione …