TNF-α increases inflammatory factor expression in synovial fibroblasts through the toll-like receptor-3-mediated ERK/AKT signaling pathway in a mouse model of …
FY Yu, CQ Xie, CL Jiang, JT Sun… - Molecular medicine …, 2018 - spandidos-publications.com
Osteoarthritis is a type of joint disease that may lead to other joint diseases. Previous
research has demonstrated that tumor necrosis factor (TNF)-α is associated with …
research has demonstrated that tumor necrosis factor (TNF)-α is associated with …
TNF‑α increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate‑induced …
H Li, S Xie, Y Qi, H Li, R Zhang… - Experimental and …, 2018 - spandidos-publications.com
Osteoarthritis is a degenerative disease that often causes patients to experience joint pain
and deformity. It has been demonstrated that tumor necrosis factor (TNF)‑α is associated …
and deformity. It has been demonstrated that tumor necrosis factor (TNF)‑α is associated …
TGF‐β‐activated kinase‐1 inhibitor LL‐Z1640‐2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 …
H Tenshin, J Teramachi, M Ashtar… - Clinical & …, 2022 - Wiley Online Library
Objectives Aberrant NLRP3 inflammasome activation has been demonstrated in rheumatoid
arthritis (RA), which may contribute to debilitating inflammation and bone destruction. Here …
arthritis (RA), which may contribute to debilitating inflammation and bone destruction. Here …
The catabolic role of toll‐like receptor 2 (TLR‐2) mediated by the NF‐κB pathway in septic arthritis
I Papathanasiou, KN Malizos… - Journal of …, 2011 - Wiley Online Library
Toll‐like receptors (TLRs) are involved in mediating cell activation on stimulation with
microbial components. Our objective was to investigate the role of TLR‐2 mediated by the …
microbial components. Our objective was to investigate the role of TLR‐2 mediated by the …
TLR4-mediated IL-12 production enhances IFN-γ and IL-1β production, which inhibits TGF-β production and promotes antibody-induced joint inflammation
HS Kim, DH Chung - Arthritis Research & Therapy, 2012 - Springer
Introduction Toll-like receptor (TLR) 4 promotes joint inflammation in mice. Despite that
several studies report a functional link between TLR4 and interleukin-(IL-) 1β in arthritis …
several studies report a functional link between TLR4 and interleukin-(IL-) 1β in arthritis …
ERK2 and JNK1 contribute to TNF-α-induced IL-8 expression in synovial fibroblasts
S Namba, R Nakano, T Kitanaka, N Kitanaka… - PloS one, 2017 - journals.plos.org
Tumor necrosis factor α (TNF-α) induces the expression and secretion of interleukin 8 (IL-8),
which contributes to synovitis in rheumatoid arthritis (RA). To elucidate the mechanism of the …
which contributes to synovitis in rheumatoid arthritis (RA). To elucidate the mechanism of the …
Interleukin-1β induced activation of nuclear factor-κb can be inhibited by novel pharmacological agents in osteoarthritis
SN Lauder, SM Carty, CE Carpenter, RJ Hill… - …, 2007 - academic.oup.com
Objectives. To investigate the importance of activation of the transcription factor, nuclear
factor-κB (NF-κB) by interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) in the …
factor-κB (NF-κB) by interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) in the …
IL‑1β increases the expression of inflammatory factors in synovial fluid‑derived fibroblast‑like synoviocytes via activation of the NF‑κB‑mediated ERK‑STAT1 signaling …
J Yang, J Wang, X Liang, H Zhao… - Molecular …, 2019 - spandidos-publications.com
Abstract Interleukin (IL)‑1β serves a crucial role in the progression of rheumatoid arthritis.
Previous studies have indicated that the ERK/STAT1 signaling pathway may be involved in …
Previous studies have indicated that the ERK/STAT1 signaling pathway may be involved in …
[HTML][HTML] Protective effect of resveratrol against IL-1β-induced inflammatory response on human osteoarthritic chondrocytes partly via the TLR4/MyD88/NF-κB signaling …
L Liu, H Gu, H Liu, Y Jiao, K Li, Y Zhao, L An… - International journal of …, 2014 - mdpi.com
Resveratrol is a natural polyphenolic compound that prevents inflammation in chondrocytes
and animal models of osteoarthritis (OA) via yet to be defined mechanisms. The purpose of …
and animal models of osteoarthritis (OA) via yet to be defined mechanisms. The purpose of …
[HTML][HTML] Effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis: an in vivo and in vitro study
YX Liu, GD Wang, X Wang, YL Zhang, TL Zhang - Oncotarget, 2017 - ncbi.nlm.nih.gov
The study aims to explore the effects of TLR-2/NF-κB signaling pathway on the occurrence of
degenerative knee osteoarthritis (OA). Degenerative knee OA and normal cartilage samples …
degenerative knee osteoarthritis (OA). Degenerative knee OA and normal cartilage samples …